Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 16/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.75 |
| ▸ | LMNA | P02545 | 3/20 | 0.75 |
| ▸ | TP53 | P04637 | 3/20 | 0.75 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.75 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.75 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.75 |
| ▸ | STAT6 | P42226 | 2/20 | 0.75 |
| ▸ | MAPT | P10636 | 2/20 | 0.75 |
| ▸ | CASP1 | P29466 | 1/20 | 0.75 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.75 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.75 |
| ▸ | RELA | Q04206 | 1/20 | 0.75 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.75 |
| ▸ | TSHR | P16473 | 1/20 | 0.75 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.75 |
| ▸ | THPO | P40225 | 1/20 | 0.75 |
| ▸ | HTT | P42858 | 1/20 | 0.75 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.75 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.75 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Melampomagnolide B SCHEMBL16229963 | 1.00 | PKM (1.00) | PKMALDH1A1LMNATP53CYP3A4 | |
| Melampomagnolide B SCHEMBL16706262 | 1.00 | PKM (1.00) | PKMALDH1A1LMNATP53CYP3A4 | |
| Melampomagnolide B SCHEMBL30081323 | 1.00 | PKM (1.00) | PKMALDH1A1LMNATP53CYP3A4 | |
| Melampomagnolide B SCHEMBL16922753 | 1.00 | PKM (1.00) | PKMALDH1A1LMNATP53CYP3A4 | |
| Melampomagnolide B SCHEMBL4761798 | 1.00 | PKM (1.00) | PKMALDH1A1LMNATP53CYP3A4 | |
| SCHEMBL16922765 | 0.90 | PKM (0.81) | PKMALDH1A1LMNATP53CYP3A4 | |
| SCHEMBL17815651 | 0.88 | PKM (0.78) | PKMALDH1A1LMNATP53CYP3A4 | |
| SCHEMBL17815618 | 0.87 | PKM (0.82) | PKMALDH1A1LMNATP53CYP3A4 | |
| SCHEMBL17815545 | 0.86 | PKM (0.76) | PKMALDH1A1LMNATP53CYP3A4 | |
| SCHEMBL17815643 | 0.86 | PKM (0.76) | PKMALDH1A1LMNATP53CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 32 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230125667-A1 | NOVEL TDZD ANALOGS AS AGENTS THAT DELAY, PREVENT, OR REVERSE AGE-ASSOCIATED DISEASES AND AS ANTI-CANCER AND ANTILEUKEMIC AGENTS | US GOV VETERANS AFFAIRS (US) | 2023-04-27 | — | — | US | disclosed |
| US-20230125667-A1 | NOVEL TDZD ANALOGS AS AGENTS THAT DELAY, PREVENT, OR REVERSE AGE-ASSOCIATED DISEASES AND AS ANTI-CANCER AND ANTILEUKEMIC AGENTS | US GOV VETERANS AFFAIRS (US) | 2023-04-27 | — | — | US | disclosed |
| WO-2021163572-A1 | NOVEL TDZD ANALOGS AS AGENTS THAT DELAY, PREVENT, OR REVERSE AGE-ASSOCIATED DISEASES; AND AS ANTI-CANCER AND ANTILEUKEMIC AGENTS | BOWROJU SURESH KUARM (US) | 2021-08-19 | — | — | WO | disclosed |
| US-10428082-B2 | Triazole derivatives of melampomagnolide B and methods of use thereof | BIOVENTURES, LLC (US) | 2019-10-01 | — | — | US | disclosed |
| US-20190040077-A1 | TRIAZOLE DERIVATIVES OF MELAMPOMAGNOLIDE B AND METHODS OF USE THEREOF | BOARD OF TRUSTEES OF THE UNIVERSITY OF ARKANSAS | 2019-02-07 | — | — | US | disclosed |
| US-9981990-B2 | Melampomagnolide B dimers | BIOVENTURES, LLC (US) | 2018-05-29 | — | — | US | disclosed |
| US-9981990-B2 | Melampomagnolide B dimers | BIOVENTURES, LLC (US) | 2018-05-29 | — | — | US | disclosed |
| US-9920063-B2 | Melampomagnolide B derivatives | BIOVENTURES, LLC (US) | 2018-03-20 | — | — | US | disclosed |
| US-9920063-B2 | Melampomagnolide B derivatives | BIOVENTURES, LLC (US) | 2018-03-20 | — | — | US | disclosed |
| US-9908892-B2 | Melampomagnolide B derivatives | BIOVENTURES, LLC (US) | 2018-03-06 | — | — | US | disclosed |
| US-20160083397-A1 | PARTHENOLIDE DERIVATIVES AND THEIR MODULATION OF PROCESSES CONTROLLED BY REGULATED TRANSLATION | BIOVENTURES, LLC | 2016-03-24 | — | — | US | disclosed |
| US-20160083397-A1 | PARTHENOLIDE DERIVATIVES AND THEIR MODULATION OF PROCESSES CONTROLLED BY REGULATED TRANSLATION | BIOVENTURES, LLC | 2016-03-24 | — | — | US | disclosed |
| US-20150203508-A1 | MELAMPOMAGNOLIDE B DERIVATIVES | BIOVENTURES, LLC | 2015-07-23 | — | — | US | disclosed |
| US-20150203508-A1 | MELAMPOMAGNOLIDE B DERIVATIVES | BIOVENTURES, LLC | 2015-07-23 | — | — | US | disclosed |
| US-20150133444-A1 | MELAMPOMAGNOLIDE B DERIVATIVES | BIOVENTURES, LLC | 2015-05-14 | — | — | US | disclosed |
| US-20150133444-A1 | MELAMPOMAGNOLIDE B DERIVATIVES | BIOVENTURES, LLC | 2015-05-14 | — | — | US | disclosed |
| US-8884027-B2 | Melampomagnolide B derivatives as antileukemic and cytotoxic agents | UNIVERSITY OF ROCHESTER (US) | 2014-11-11 | — | — | US | disclosed |
| US-8884027-B2 | Melampomagnolide B derivatives as antileukemic and cytotoxic agents | UNIVERSITY OF ROCHESTER (US) | 2014-11-11 | — | — | US | disclosed |
| US-20120122943-A1 | Melampomagnolide B Derivatives as Antileukemic and Cytotoxic Agents | UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION (US) | 2012-05-17 | — | — | US | disclosed |
| US-20120122943-A1 | Melampomagnolide B Derivatives as Antileukemic and Cytotoxic Agents | UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION (US) | 2012-05-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150203508-A1 | MELAMPOMAGNOLIDE B DERIVATIVES | CMBL, MGMT, MMAB | PKM 2854/4885ALDH1A1 2275/4885LMNA 3553/4885 |
| US-20150133444-A1 | MELAMPOMAGNOLIDE B DERIVATIVES | CMBL, STK32B, MMAB | PKM 2534/4885ALDH1A1 2434/4885LMNA 3839/4885 |
| US-20230125667-A1 | NOVEL TDZD ANALOGS AS AGENTS THAT DELAY, PREVENT, OR REVERSE AGE-ASSOCIATED DISEASES AND AS ANTI-CANCER AND ANTILEUKEMIC AGENTS | BRCA1, MTPN, MUSK | PKM 1214/4885ALDH1A1 4054/4885LMNA 1753/4885 |
| US-20190040077-A1 | TRIAZOLE DERIVATIVES OF MELAMPOMAGNOLIDE B AND METHODS OF USE THEREOF | MCL1, MYADM, PHKB | PKM 2815/4885ALDH1A1 2298/4885LMNA 1559/4885 |
| US-10428082-B2 | Triazole derivatives of melampomagnolide B and methods of use thereof | MCL1, MYADM, PHKB | PKM 2815/4885ALDH1A1 2298/4885LMNA 1559/4885 |
| US-20160083397-A1 | PARTHENOLIDE DERIVATIVES AND THEIR MODULATION OF PROCESSES CONTROLLED BY REGULATED TRANSLATION | EIF4EBP1, RIOX2, RPL7A | PKM 1546/4885ALDH1A1 3684/4885LMNA 2030/4885 |
| US-20120122943-A1 | Melampomagnolide B Derivatives as Antileukemic and Cytotoxic Agents | MCL1, MYADM, BPGM | PKM 2686/4885ALDH1A1 957/4885LMNA 148/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.