Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 9/20 | 0.36 |
| ▸ | BRD2 | P25440 | 2/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.33 |
| ▸ | USP30 | Q70CQ3 | 4/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | AR | P10275 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | USP2 | O75604 | 1/20 | 0.31 |
| ▸ | BRD3 | Q15059 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12800965 | 0.77 | TLR8 (0.40) | BRD4BRD2CYP3A4CYP2D6CYP2C19 | |
| SCHEMBL1670383 | 0.75 | BRD4 (0.40) | BRD4BRD2USP30AR | |
| SCHEMBL1670709 | 0.73 | PTGS2 (0.48) | BRD4BRD2NPSR1BRD3 | |
| SCHEMBL1670817 | 0.69 | MLYCD (0.40) | BRD4BRD2USP30AR | |
| SCHEMBL16411423 | 0.68 | HDAC8 (0.32) | — | |
| SCHEMBL1673047 | 0.66 | IMPDH2 (0.31) | — | |
| SCHEMBL1682484 | 0.64 | BRD4 (0.40) | BRD4BRD2USP30AR | |
| SCHEMBL25975652 | 0.62 | BRD4 (0.59) | BRD4BRD2USP30ARBRD3 | |
| SCHEMBL15106914 | 0.60 | TLR8 (0.45) | BRD4BRD2CYP3A4CYP2C19TLR8 | |
| SCHEMBL18812499 | 0.59 | BRD4 (0.51) | BRD4BRD2CYP3A4ALDH1A1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011042477-A1 | SUBSTITUTED PYRROLES AND IMIDAZOLES AS ESTROGEN RECEPTOR LIGANDS | KARO BIO AB (SE) | 2011-04-14 | — | — | WO | disclosed |