Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.36 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.36 |
| ▸ | MAP2K3 | P46734 | 1/20 | 0.36 |
| ▸ | ADORA2B | P29275 | 4/20 | 0.34 |
| ▸ | JAK2 | O60674 | 1/20 | 0.34 |
| ▸ | CDC7 | O00311 | 3/20 | 0.34 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.34 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.34 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.34 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.34 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.33 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | SRC | P12931 | 1/20 | 0.33 |
| ▸ | BRAF | P15056 | 1/20 | 0.33 |
| ▸ | KDR | P35968 | 1/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.33 |
| ▸ | CYP46A1 | Q9Y6A2 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14917438 | 0.79 | SRC (0.48) | MAP2K3CDC7SRCBRAFKDR | |
| SCHEMBL28177811 | 0.76 | P2RX7 (0.39) | HSP90AA1P2RX7MAP2K3ADORA2BJAK2 | |
| SCHEMBL16713266 | 0.75 | ADORA2B (0.37) | HSP90AA1P2RX7ADORA2BJAK2CDC7 | |
| SCHEMBL14917460 | 0.72 | MEN1 (0.47) | MAP2K3CDC7HTTHSD17B10SRC | |
| SCHEMBL14917433 | 0.71 | MKNK1 (0.50) | HSP90AA1MKNK1CDK5CDK5R1 | |
| SCHEMBL15380562 | 0.70 | MKNK1 (0.44) | CDC7HTTHSD17B10MKNK1 | |
| SCHEMBL25424428 | 0.70 | CHRNB2 (0.41) | JAK2CDC7MAPK9MAPK10MAPK11 | |
| SCHEMBL4794766 | 0.70 | CDC7 (0.42) | ADORA2BJAK2CDC7CCNT1CDK2 | |
| SCHEMBL9081105 | 0.69 | P2RX7 (0.39) | HSP90AA1P2RX7MAP2K3ADORA2BJAK2 | |
| SCHEMBL7098629 | 0.69 | PARP1 (0.42) | HSP90AA1P2RX7MAP2K3JAK2CDC7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9416125-B2 | — | — | 2016-08-16 | — | — | US | disclosed |
| US-20150141372-A1 | SUBSTITUTED CYCLOALKENOPYRAZOLES AS BUB1 INHIBITORS FOR THE TREATMENT OF CANCER | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2015-05-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150141372-A1 | SUBSTITUTED CYCLOALKENOPYRAZOLES AS BUB1 INHIBITORS FOR THE TREATMENT OF CANCER | BUB1, BUB1B, BUB3 | HSP90AA1 740/4885P2RX7 4801/4885MAP2K3 654/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.