SCHEMBL16716952

SCHEMBL16716952

C[C@H]1C[C@@H](O)CCN1C(=O)O

nearest known ligand 0.33

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
MAPT P10636 1/20 0.33
ATM Q13315 1/20 0.33
ENPP2 Q13822 2/20 0.32
LMNA P02545 1/20 0.32
CYP2C9 P11712 1/20 0.32
GAA P10253 2/20 0.31
HPGD P15428 1/20 0.31
TSHR P16473 1/20 0.31
SMYD3 Q9H7B4 1/20 0.30
TDP1 Q9NUW8 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16717657 1.00 MAPT (0.33) MAPTATMENPP2LMNACYP2C9
SCHEMBL3645212 1.00 MAPT (0.33) MAPTATMENPP2LMNACYP2C9
SCHEMBL16716948 1.00 MAPT (0.33) MAPTATMENPP2LMNACYP2C9
SCHEMBL16717660 1.00 MAPT (0.33) MAPTATMENPP2LMNACYP2C9
SCHEMBL19617642 1.00 MAPT (0.33) MAPTATMENPP2LMNACYP2C9
SCHEMBL23275047 1.00 MAPT (0.33) MAPTATMENPP2LMNACYP2C9
SCHEMBL20422022 1.00 MAPT (0.33) MAPTATMENPP2LMNACYP2C9
SCHEMBL19765483 0.83 ATM (0.41) MAPTATMENPP2LMNACYP2C9
SCHEMBL19765490 0.83 ATM (0.41) MAPTATMENPP2LMNACYP2C9
SCHEMBL25153145 0.83 ATM (0.41) MAPTATMENPP2LMNACYP2C9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 61 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12030872-B2 N-heteroaryl indazole derivatives as LRRK2 inhibitors, pharmaceutical compositions, and uses thereof MERCK SHARP & DOHME LLC (US) 2024-07-09 US disclosed
US-11999726-B2 5-methyl-4-fluoro-thiazol-2-yl compounds ELI LILLY AND COMPANY 2024-06-04 US disclosed
CN-113423711-B Thieno [3,2-B ] pyridine derivatives as UDP glycosyltransferase inhibitors and methods of use thereof 建新公司 2024-03-15 CN disclosed
WO-2024026338-A1 N-HETEROCYLIC GPCR RECEPTOR AGONISTS, PHARMACEUTICAL COMPOSITIONS COMPRISING THE SAME, AND METHODS FOR THEIR USE CARMOT THERAPEUTICS, INC. (US) 2024-02-01 WO disclosed
US-11839654-B2 Combination therapy ELI LILLY AND COMPANY (US) 2023-12-12 US disclosed
EP-4284795-A1 GPCR RECEPTOR AGONISTS, PHARMACEUTICAL COMPOSITIONS COMPRISING THE SAME, AND METHODS FOR THEIR USE Carmot Therapeutics, Inc. (US) 2023-12-06 EP disclosed
US-20230219897-A1 PYRAZOLE MAGL INHIBITORS H. LUNDBECK A/S (DK) 2023-07-13 US disclosed
EP-4198024-A1 PYRAZOLE MAGL INHIBITORS H. Lundbeck A/S (DK) 2023-06-21 EP disclosed
US-11655217-B2 Pyrazole MAGL inhibitors H. LUNDBECK A/S (DK) 2023-05-23 US disclosed
WO-2023070064-A1 O-GLCNACASE (OGA) INHIBITOR COMBINATION THERAPY ELI LILLY AND COMPANY (US) 2023-04-27 WO disclosed
US-20180215751-A1 5-METHYL-1,2,4-OXADIAZOL-3-YL COMPOUNDS ELI LILLY AND COMPANY (US) 2018-08-02 US disclosed
WO-2018140299-A1 N-[4-FLUORO-5-[[(2S,4S)-2-METHYL-4-[(5-METHYL-1,2,4-OXADIAZOL-3-YL)METHOXY]-1-PIPERIDYL]METHYL]THIAZOL-2-YL]ACETAMIDE AS OGA INHIBITOR ELI LILLY AND COMPANY (US) 2018-08-02 WO disclosed
WO-2017106556-A1 TANK-BINDING KINASE INHIBITOR COMPOUNDS GILEAD SCIENCES, INC. (US) 2017-06-22 WO disclosed
US-20170174713-A1 TANK-BINDING KINASE INHIBITOR COMPOUNDS GILEAD SCIENCES, INC. 2017-06-22 US disclosed
EP-3071203-A2 TETRAHYDROQUINOLINE COMPOSITIONS AS BET BROMODOMAIN INHIBITORS Forma Therapeutics, Inc. (US) 2016-09-28 EP disclosed
US-20160257692-A1 TETRAHYDROQUINOLINE COMPOSITIONS AS BET BROMODOMAIN INHIBITORS FORMA THERAPEUTICS, INC. 2016-09-08 US disclosed
US-20160256448-A1 TETRAHYDROQUINOLINE COMPOSITIONS AS BET BROMODOMAIN INHIBITORS FORMA THERAPEUTICS, INC. 2016-09-08 US disclosed
US-9388161-B2 Tetrahydroquinoline compositions as BET bromodomain inhibitors FORMA THERAPEUTICS, INC. (US) 2016-07-12 US disclosed
US-20150232445-A1 TETRAHYDROQUINOLINE COMPOSITIONS AS BET BROMODOMAIN INHIBITORS FORMA THERAPEUTICS, INC. 2015-08-20 US disclosed
WO-2015074064-A2 TETRAHYDROQUINOLINE COMPOSITIONS AS BET BROMODOMAIN INHIBITORS BAIR KENNETH W (US) 2015-05-21 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (10 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20160256448-A1 TETRAHYDROQUINOLINE COMPOSITIONS AS BET BROMODOMAIN INHIBITORS BRD4, BRD3, BRD1 MAPT 3708/4885ATM 2014/4885ENPP2 1329/4885
US-20180215751-A1 5-METHYL-1,2,4-OXADIAZOL-3-YL COMPOUNDS PSEN1, PSEN2, MAPT MAPT 3/4885ATM 2823/4885ENPP2 2664/4885
US-12030872-B2 N-heteroaryl indazole derivatives as LRRK2 inhibitors, pharmaceutical compositions, and uses thereof LRRK2, CLK2, BRSK2 MAPT 536/4885ATM 288/4885ENPP2 3949/4885
US-20230219897-A1 PYRAZOLE MAGL INHIBITORS MGLL, PNLIP, LPL MAPT 2499/4885ATM 2352/4885ENPP2 1139/4885
US-20150232445-A1 TETRAHYDROQUINOLINE COMPOSITIONS AS BET BROMODOMAIN INHIBITORS BRD4, BRD3, BRD1 MAPT 3708/4885ATM 2014/4885ENPP2 1329/4885
US-11655217-B2 Pyrazole MAGL inhibitors MGLL, PNLIP, LPL MAPT 2487/4885ATM 2601/4885ENPP2 1311/4885
US-11839654-B2 Combination therapy MAPT, OGA, OAT MAPT 1/4885ATM 976/4885ENPP2 1135/4885
US-20170174713-A1 TANK-BINDING KINASE INHIBITOR COMPOUNDS TBKBP1, TNKS1BP1, TNKS MAPT 2232/4885ATM 317/4885ENPP2 2930/4885
US-20160257692-A1 TETRAHYDROQUINOLINE COMPOSITIONS AS BET BROMODOMAIN INHIBITORS BRD4, BRD3, BRD1 MAPT 3708/4885ATM 2014/4885ENPP2 1329/4885
US-11999726-B2 5-methyl-4-fluoro-thiazol-2-yl compounds MAPT, PSEN2, PSEN1 MAPT 1/4885ATM 2476/4885ENPP2 3127/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.