SCHEMBL1673256

SCHEMBL1673256

O=C(O)Cn1ccc(=O)[nH]c1=S

nearest known ligand 0.56

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 4/20 0.42
ALDH1A1 P00352 6/20 0.42
LMNA P02545 2/20 0.42
KDM4E B2RXH2 3/20 0.39
MAPT P10636 3/20 0.39
POLB P06746 1/20 0.39
MEN1 O00255 3/20 0.37
ATM Q13315 1/20 0.37
RECQL P46063 2/20 0.37
ALOX12 P18054 1/20 0.37
CA1 P00915 2/20 0.36
CA2 P00918 2/20 0.36
CA4 P22748 2/20 0.36
CA9 Q16790 2/20 0.36
TDP1 Q9NUW8 1/20 0.36
DUT P33316 4/20 0.35
TSHR P16473 1/20 0.35
PKM P14618 1/20 0.35
L3MBTL1 Q9Y468 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30424240 0.84 KMT2A (0.43) KMT2AALDH1A1LMNAKDM4EMAPT
SCHEMBL2899640 0.81 ALDH1A1 (0.59) KMT2AALDH1A1LMNAKDM4EMEN1
SCHEMBL20529215 0.80 ALDH1A1 (0.44) KMT2AALDH1A1LMNAKDM4EMEN1
SCHEMBL2227451 0.79 ALDH1A1 (0.38) KMT2AALDH1A1LMNAKDM4EMAPT
SCHEMBL5792152 0.77 CRBN (0.42) ALDH1A1LMNACA1CA2CA4
Glycine SCHEMBL2322499 0.77 DUT (0.39) ALDH1A1LMNADUTPKM
SCHEMBL11581000 0.76 ALDH1A1 (0.43) ALDH1A1LMNADUTPKML3MBTL1
SCHEMBL28803795 0.76 ALDH1A1 (0.54) KMT2AALDH1A1LMNAKDM4EMEN1
SCHEMBL8656960 0.76 PKM (0.45) ALDH1A1LMNAKDM4EDUTPKM
SCHEMBL7752441 0.75 PKM (0.38) KMT2AALDH1A1LMNAMAPTMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 39 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20200292535-A1 METHOD FOR EVALUATION OF TARGET IN HISTOLOGICAL SAMPLE DAKO DENMARK A/S (DK) 2020-09-17 US disclosed
US-10648970-B2 Method for evaluation of target in histological sample AGILENT TECHNOLOGIES, INC. (US) 2020-05-12 US disclosed
EP-2646795-B1 METHODS FOR ANALYZING IMAGES OF SPECIMENS PROCESSED BY A PROGRAMMABLE QUANTITATIVE ASSAY DAKO DENMARK AS (DK) 2019-02-20 EP disclosed
US-10180426-B2 Quantification of single target molecules in histological samples DAKO DENMARK A/S (DK) 2019-01-15 US disclosed
US-9970874-B2 Methods and systems for analyzing images of specimens processed by a programmable quantitative assay DAKO DENMARK A/S (DK) 2018-05-15 US disclosed
US-9958449-B2 Method for enzyme-mediated signal amplification DAKO DENMARK A/S (DK) 2018-05-01 US disclosed
EP-2699691-B1 NEW METHOD FOR ENZYME-MEDIATED SIGNAL AMPLIFICATION DAKO DENMARK AS (DK) 2017-10-18 EP disclosed
US-9671400-B2 Conjugate molecules DAKO DENMARK A/S (DK) 2017-06-06 US disclosed
EP-2788757-B1 NEW METHOD FOR EVALUATION OF TARGET IN HISTOLOGICAL SAMPLE DAKO DENMARK AS (DK) 2016-12-21 EP disclosed
CN-103201627-B Quantification of single target molecules in histological samples 丹麦达科有限公司 2016-10-12 CN disclosed
EP-2491390-A1 IMMUNOCHEMICAL DETECTION OF SINGLE TARGET ENTITIES Dako Denmark A/S (DK) 2012-08-29 EP disclosed
US-20120163681-A1 METHODS AND SYSTEMS FOR ANALYZING IMAGES OF SPECIMENS PROCESSED BY A PROGRAMMABLE QUANTITATIVE ASSAY DAKO DENMARK APS (DK) 2012-06-28 US disclosed
WO-2012075028-A1 METHODS AND SYSTEMS FOR ANALYZING IMAGES OF SPECIMENS PROCESSED BY A PROGRAMMABLE QUANTITATIVE ASSAY DAKO DENMARK A/S (DK) 2012-06-07 WO disclosed
WO-2012062318-A1 QUANTIFICATION OF SINGLE TARGET MOLECULES IN HISTOLOGICAL SAMPLES DAKO DENMARK A/S (DK) 2012-05-18 WO disclosed
CN-102325895-A Conjugate molecules DAKO DENMARK AS 2012-01-18 CN disclosed
WO-2011047680-A1 IMMUNOCHEMICAL DETECTION OF SINGLE TARGET ENTITIES DAKO DENMARK A/S (DK) 2011-04-28 WO disclosed
US-20100240085-A1 CONJUGATE MOLECULES DAKO DENMARK APS (DK) 2010-09-23 US disclosed
US-20100240047-A1 METHODS AND COMPOUNDS FOR DETECTION OF MOLECULAR TARGETS DAKO DENMARK APS (DK) 2010-09-23 US disclosed
WO-2010094284-A1 METHODS AND COMPOUNDS FOR DETECTION OF MOLECULAR TARGETS DAKO DENMARK A/S (DK) 2010-08-26 WO disclosed
WO-2010094283-A1 CONJUGATE MOLECULES DAKO DENMARK A/S (DK) 2010-08-26 WO disclosed