Sugi Predict

Sugi Predict / Compounds / SCHEMBL167328

SCHEMBL167328

SCHEMBL167328

CN1CCc2[nH]c3ccc(Cl)cc3c2C1

nearest known ligand 0.70

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
▸ L3MBTL1 Q9Y468 1/20 0.70
▸ BAZ2B Q9UIF8 2/20 0.66
▸ ALOX15 P16050 2/20 0.65
▸ HSD17B10 Q99714 2/20 0.65
▸ USP2 O75604 1/20 0.65
▸ CYP1A2 P05177 1/20 0.65
▸ CYP2D6 P10635 1/20 0.65
▸ CYP2C9 P11712 1/20 0.65
▸ CHRNA7 P36544 1/20 0.64
▸ SIRT2 Q8IXJ6 1/20 0.61
▸ HTR6 P50406 4/20 0.60
▸ POLB P06746 2/20 0.58
▸ GAA P10253 1/20 0.58
▸ KDM4E B2RXH2 1/20 0.56
▸ ALDH1A1 P00352 1/20 0.56
▸ MAPK1 P28482 1/20 0.56

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12351353 0.92 BAZ2B (0.60) L3MBTL1BAZ2BALOX15HSD17B10USP2
SCHEMBL3231659 0.90 BAZ2B (0.60) L3MBTL1BAZ2BALOX15HSD17B10USP2
SCHEMBL1120485 0.88 KDM4E (0.64) L3MBTL1BAZ2BALOX15HSD17B10USP2
SCHEMBL168351 0.88 CHRNA7 (0.64) L3MBTL1BAZ2BALOX15HSD17B10USP2
Dehydrostobadine SCHEMBL167500 0.84 L3MBTL1 (0.97) L3MBTL1BAZ2BALOX15HSD17B10USP2
Dehydrostobadine SCHEMBL29468212 0.84 L3MBTL1 (0.97) L3MBTL1BAZ2BALOX15HSD17B10USP2
SCHEMBL30704375 0.82 ACHE (0.60) BAZ2BHTR6
SCHEMBL19252850 0.82 L3MBTL1 (0.70) L3MBTL1BAZ2BALOX15HSD17B10USP2
SCHEMBL3024458 0.82 L3MBTL1 (0.70) L3MBTL1ALOX15HSD17B10USP2CYP1A2
SCHEMBL2186097 0.82 L3MBTL1 (0.70) L3MBTL1BAZ2BALOX15HSD17B10USP2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 89 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240197694-A1 MODIFIED PROTEINS AND PROTEIN BINDERS CULLGEN (SHANGHAI), INC. (CN) 2024-06-20 — — US disclosed
US-9550782-B2 Compounds and methods for treating diabetes MEDIVATION TECHNOLOGIES, INC. (US) 2017-01-24 — — US disclosed
US-9527854-B2 Compounds and methods for treatment of hypertension MEDIVATION TECHNOLOGIES, INC. (US) 2016-12-27 — — US disclosed
US-9458155-B2 Pyrido[4,3-b]indoles containing rigid moieties MEDIVATION TECHNOLOGIES, INC (US) 2016-10-04 — — US disclosed
US-9458155-B2 Pyrido[4,3-b]indoles containing rigid moieties MEDIVATION TECHNOLOGIES, INC (US) 2016-10-04 — — US disclosed
US-9458155-B2 Pyrido[4,3-b]indoles containing rigid moieties MEDIVATION TECHNOLOGIES, INC (US) 2016-10-04 — — US disclosed
EP-2424366-B1 PYRIDO [4, 3-B]INDOLES AND METHODS OF USE MEDIVATION TECHNOLOGIES INC (US) 2016-02-17 — — EP disclosed
US-9255094-B2 Pyrido[4,3-B]indoles and methods of use MEDIVATION TECHNOLOGIES, INC. (US) 2016-02-09 — — US disclosed
US-9211287-B2 Pyrido[4,3-b]indole and pyrido[3,4-b]indole derivatives and methods of use MEDIVATION TECHNOLOGIES, INC. (US) 2015-12-15 — — US disclosed
US-9211287-B2 Pyrido[4,3-b]indole and pyrido[3,4-b]indole derivatives and methods of use MEDIVATION TECHNOLOGIES, INC. (US) 2015-12-15 — — US disclosed
US-20100216814-A1 PYRIDO[4,3-B]INDOLES CONTAINING RIGID MOIETIES MEDIVATION TECHNOLOGIES, INC. 2010-08-26 — — US disclosed
EP-2217598-A1 NEW TETRACYCLIC COMPOUNDS Medivation Technologies, Inc. (US) 2010-08-18 — — EP disclosed
EP-2184064-A2 LIGANDS OF 5-HT6 RECEPTORS, A PHARMACEUTICAL COMPOSITION, METHOD FOR THE PRODUCTION AND USE THEREOF Alla Chem, LLC. (US) 2010-05-12 — — EP disclosed
WO-2010051501-A1 PYRIDO (4,3-B) INDOLES CONTAINING RIGID MOIETIES MEDIVATION TECHNOLOGIES, INC. (US) 2010-05-06 — — WO disclosed
WO-2010051501-A1 PYRIDO (4,3-B) INDOLES CONTAINING RIGID MOIETIES MEDIVATION TECHNOLOGIES, INC. (US) 2010-05-06 — — WO disclosed
US-20100022580-A1 NEW 2,3,4,5-TETRAHYDRO-1H-PYRIDO[4,3-B]INDOLE COMPOUNDS AND METHODS OF USE THEREOF MEDIVATION TECHNOLOGIES, INC. 2010-01-28 — — US disclosed
US-20090239854-A1 Tetracyclic compounds MEDIVATION TECHNOLOGIES, INC. 2009-09-24 — — US disclosed
WO-2009094668-A1 NEW 2,3,4,5-TERAHYDRO-1H-PYRIDO[ 4,3-B] INDOLE COMPOUNDS AND METHODS OF USE THEREOF MEDIVATION TECHNOLOGIES, INC. (US) 2009-07-30 — — WO disclosed
WO-2009055828-A1 NEW TETRACYCLIC COMPOUNDS MEDIVATION TECHNOLOGIES, INC. (US) 2009-04-30 — — WO disclosed
WO-2008060190-A2 LIGANDS OF 5-HT6 RECEPTORS, A PHARMACEUTICAL COMPOSITION, METHOD FOR THE PRODUCTION AND USE THEREOF ALLA CHEM, LLC (US) 2008-05-22 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100022580-A1 NEW 2,3,4,5-TETRAHYDRO-1H-PYRIDO[4,3-B]INDOLE COMPOUNDS AND METHODS OF USE THEREOF HTR2C, HTR3B, HTR4 L3MBTL1 4416/4885BAZ2B 1712/4885ALOX15 941/4885
US-20100216814-A1 PYRIDO[4,3-B]INDOLES CONTAINING RIGID MOIETIES HTR3B, HTR3D, HTR3A L3MBTL1 2178/4885BAZ2B 1572/4885ALOX15 788/4885
US-20240197694-A1 MODIFIED PROTEINS AND PROTEIN BINDERS DCAF1, DDB1, CUL4A L3MBTL1 1305/4885BAZ2B 98/4885ALOX15 4751/4885
US-20090239854-A1 Tetracyclic compounds HTR2C, HTR3D, HTR5A L3MBTL1 3804/4885BAZ2B 2213/4885ALOX15 1350/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.