Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G4B | P0C869 | 4/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | WDR5 | P61964 | 1/20 | 0.39 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.39 |
| ▸ | RARB | P10826 | 5/20 | 0.39 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | RXRA | P19793 | 1/20 | 0.37 |
| ▸ | PLA2G4A | P47712 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9915516 | 0.80 | PLA2G4B (0.41) | PLA2G4BTP53TSHRWDR5PTPN11 | |
| SCHEMBL9915532 | 0.77 | HPGD (0.36) | ALDH1A1HPGD | |
| SCHEMBL16748804 | 0.76 | NR1H4 (0.46) | TP53TSHR | |
| SCHEMBL16748648 | 0.76 | CDK1 (0.38) | — | |
| SCHEMBL15279055 | 0.72 | CDK1 (0.35) | TP53TSHR | |
| SCHEMBL14818596 | 0.71 | CDK1 (0.40) | ALDH1A1 | |
| SCHEMBL9915471 | 0.71 | SMN1; SMN2 (0.40) | TSHRHPGD | |
| SCHEMBL16748830 | 0.71 | CDK1 (0.37) | PTPN11 | |
| SCHEMBL9915324 | 0.69 | CDK1 (0.38) | TP53ALDH1A1 | |
| SCHEMBL14136577 | 0.69 | USP2 (0.45) | HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2646436-B1 | MONOBACTAMS | PFIZER (US) | 2015-05-27 | — | — | EP | disclosed |