Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G4B | P0C869 | 2/20 | 0.41 |
| ▸ | WDR5 | P61964 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.38 |
| ▸ | RARB | P10826 | 5/20 | 0.37 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | PLA2G2D | Q9UNK4 | 1/20 | 0.36 |
| ▸ | RXRA | P19793 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14124958 | 0.84 | NR4A1 (0.41) | HPGDRXRA | |
| SCHEMBL16748696 | 0.80 | PLA2G4B (0.43) | PLA2G4BWDR5TP53TSHRPTPN11 | |
| SCHEMBL16748648 | 0.74 | CDK1 (0.38) | — | |
| SCHEMBL16748804 | 0.72 | NR1H4 (0.46) | TP53TSHR | |
| SCHEMBL16748830 | 0.72 | CDK1 (0.37) | PTPN11 | |
| SCHEMBL15279055 | 0.71 | CDK1 (0.35) | TP53TSHR | |
| SCHEMBL9915471 | 0.70 | SMN1; SMN2 (0.40) | TSHRHPGD | |
| SCHEMBL14818596 | 0.70 | CDK1 (0.40) | ALDH1A1 | |
| SCHEMBL9915324 | 0.70 | CDK1 (0.38) | TP53ALDH1A1 | |
| SCHEMBL14136577 | 0.67 | USP2 (0.45) | HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150148326-A1 | Monobactams | PFIZER (US) | 2015-05-28 | — | — | US | disclosed |
| US-20130252935-A1 | Monobactams | PFIZER INC. (US) | 2013-09-26 | — | — | US | disclosed |
| US-20120302542-A1 | MONOBACTAMS | PFIZER INC | 2012-11-29 | — | — | US | disclosed |
| WO-2012073138-A1 | MONOBACTAMS | PFIZER INC. (US) | 2012-06-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130252935-A1 | Monobactams | MGAM, MGAM2, BPGM | PLA2G4B 1156/4885WDR5 1512/4885TP53 4737/4885 |
| US-20150148326-A1 | Monobactams | MGAM, MGAM2, BPGM | PLA2G4B 1156/4885WDR5 1512/4885TP53 4737/4885 |
| US-20120302542-A1 | MONOBACTAMS | MGAM, MGAM2, BPGM | PLA2G4B 1156/4885WDR5 1512/4885TP53 4737/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.