SCHEMBL16748862

SCHEMBL16748862

CC(C)C[C@H](OC(=O)Nc1ccc(Br)cc1)C(=O)NCCNC(=O)OC(C)(C)C

nearest known ligand 0.48

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
FPR2 P25090 10/20 0.48
FPR3 P25089 6/20 0.48
AAK1 Q2M2I8 5/20 0.48
LMNA P02545 2/20 0.44
GAA P10253 1/20 0.44
MAPT P10636 1/20 0.44
XBP1 P17861 1/20 0.44
MAPK1 P28482 1/20 0.44
USP2 O75604 1/20 0.42
MEN1 O00255 1/20 0.40
KMT2A Q03164 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19563290 0.88 FPR2 (0.47) FPR2AAK1LMNAGAAMAPT
SCHEMBL16748863 0.88 FPR2 (0.47) FPR2AAK1LMNAGAAMAPT
SCHEMBL19547869 0.85 FPR2 (0.47) FPR2LMNAMAPTMEN1KMT2A
SCHEMBL19563271 0.85 FPR2 (0.45) FPR2LMNAMAPTMEN1KMT2A
SCHEMBL18089387 0.85 FPR2 (0.45) FPR2LMNAMAPTMEN1KMT2A
SCHEMBL16748807 0.84 FPR2 (0.44) FPR2FPR3AAK1LMNAMAPT
SCHEMBL18064435 0.84 FPR2 (0.44) FPR2FPR3AAK1LMNAMAPT
SCHEMBL19563339 0.84 FPR2 (0.46) FPR2AAK1LMNAGAAMAPT
SCHEMBL16748772 0.84 FPR2 (0.46) FPR2AAK1LMNAGAAMAPT
SCHEMBL19547845 0.83 FPR2 (0.49) FPR2MEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9926264-B2 Phenylcarbamate derivatives as formyl peptide receptor modulators ALLERGAN, INC. (US) 2018-03-27 US disclosed
EP-3071548-B1 PHENYLCARBAMATE DERIVATIVES AS FORMYL PEPTIDE RECEPTOR MODULATORS ALLERGAN INC (US) 2017-11-08 EP disclosed
US-20160272581-A1 PHENYLCARBAMATE DERIVATIVES AS FORMYL PEPTIDE RECEPTOR MODULATORS ALLERGAN, INC. (US) 2016-09-22 US disclosed
WO-2015077451-A1 PHENYLCARBAMATE DERIVATIVES AS FORMYL PEPTIDE RECEPTOR MODULATORS ALLERGAN, INC. (US) 2015-05-28 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20160272581-A1 PHENYLCARBAMATE DERIVATIVES AS FORMYL PEPTIDE RECEPTOR MODULATORS FPR2, FPR1, FPR3 FPR2 1/4885FPR3 3/4885AAK1 2796/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.