Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRC | P12931 | 1/20 | 0.73 |
| ▸ | PTPN1 | P18031 | 4/20 | 0.52 |
| ▸ | TRPA1 | O75762 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.47 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.47 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.47 |
| ▸ | HTR2B | P41595 | 1/20 | 0.47 |
| ▸ | BACE1 | P56817 | 1/20 | 0.43 |
| ▸ | MGAM | O43451 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | SI | P14410 | 2/20 | 0.38 |
| ▸ | MGAM2 | Q2M2H8 | 2/20 | 0.38 |
| ▸ | APP | P05067 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29412614 | 0.84 | SRC (1.00) | SRCPTPN1TRPA1LMNACHRM1 | |
| SCHEMBL29571282 | 0.84 | SRC (1.00) | SRCPTPN1TRPA1LMNACHRM1 | |
| SCHEMBL16749882 | 0.84 | SRC (1.00) | SRCPTPN1TRPA1LMNACHRM1 | |
| SCHEMBL31545696 | 0.84 | SRC (1.00) | SRCPTPN1TRPA1LMNACHRM1 | |
| SCHEMBL16749879 | 0.84 | SRC (1.00) | SRCPTPN1TRPA1LMNACHRM1 | |
| SCHEMBL574032 | 0.77 | TRPA1 (0.53) | SRCTRPA1LMNACHRM1SLC6A2 | |
| Citronellal SCHEMBL9719537 | 0.76 | SRC (0.64) | SRCPTPN1TRPA1LMNACHRM1 | |
| SCHEMBL29966905 | 0.75 | SRC (0.78) | SRCPTPN1TRPA1LMNACHRM1 | |
| SCHEMBL11138508 | 0.74 | LMNA (0.59) | SRCTRPA1LMNACHRM1SLC6A2 | |
| SCHEMBL19578003 | 0.74 | TRPA1 (0.50) | SRCTRPA1LMNACHRM1SLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220105051-A1 | COMPOUNDS FOR INCREASING MHC-I EXPRESSION AND MODULATING HISTONE DEACETYLASE ACTIVITY | Cava Healthcare Inc. (CA) | 2022-04-07 | — | — | US | disclosed |
| US-11197832-B2 | Curcuphenol compounds for increasing MHC-I expression | Cava Healthcare Inc. (CA) | 2021-12-14 | — | — | US | disclosed |
| US-20200375917-A1 | CURCUPHENOL COMPOUNDS FOR INCREASING MHC-I EXPRESSION | BIOMMUNE TECHNOLOGIES INC. (CA) | 2020-12-03 | — | — | US | disclosed |
| WO-2020154811-A9 | COMPOUNDS FOR INCREASING MHC-I EXPRESSION AND MODULATING HISTONE DEACETYLASE ACTIVITY | Cava Healthcare Inc. (CA) | 2020-09-17 | — | — | WO | disclosed |
| WO-2020154811-A1 | COMPOUNDS FOR INCREASING MHC-I EXPRESSION AND MODULATING HISTONE DEACETYLASE ACTIVITY | Cava Healthcare Inc. (CA) | 2020-08-06 | — | — | WO | disclosed |
| US-20150147314-A1 | CURCUPHENOL COMPOUNDS FOR INCREASING MHC-I EXPRESSION | JEFFERIES, WILFRED (CA) | 2015-05-28 | — | — | US | disclosed |
| US-20150147314-A1 | CURCUPHENOL COMPOUNDS FOR INCREASING MHC-I EXPRESSION | JEFFERIES, WILFRED (CA) | 2015-05-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220105051-A1 | COMPOUNDS FOR INCREASING MHC-I EXPRESSION AND MODULATING HISTONE DEACETYLASE ACTIVITY | HDAC1, TAP1, HDAC11 | SRC 2561/4885PTPN1 2769/4885TRPA1 407/4885 |
| US-11197832-B2 | Curcuphenol compounds for increasing MHC-I expression | CD74, MICA, HLA-DRB1 | SRC 2209/4885PTPN1 2945/4885TRPA1 190/4885 |
| US-20200375917-A1 | CURCUPHENOL COMPOUNDS FOR INCREASING MHC-I EXPRESSION | CD74, MICA, HLA-DRB1 | SRC 2209/4885PTPN1 2945/4885TRPA1 190/4885 |
| US-20150147314-A1 | CURCUPHENOL COMPOUNDS FOR INCREASING MHC-I EXPRESSION | CD74, MICA, HLA-DRB1 | SRC 2209/4885PTPN1 2945/4885TRPA1 190/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.