Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPA1 | O75762 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.50 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.50 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.50 |
| ▸ | HTR2B | P41595 | 1/20 | 0.50 |
| ▸ | SRC | P12931 | 1/20 | 0.44 |
| ▸ | CNR1 | P21554 | 2/20 | 0.39 |
| ▸ | CNR2 | P34972 | 2/20 | 0.39 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.39 |
| ▸ | IDO1 | P14902 | 1/20 | 0.36 |
| ▸ | TDO2 | P48775 | 1/20 | 0.36 |
| ▸ | PDE5A | O76074 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL574032 | 0.83 | TRPA1 (0.53) | TRPA1LMNACHRM1SLC6A2ADRA1A | |
| SCHEMBL22137732 | 0.78 | TRPA1 (0.47) | TRPA1LMNACHRM1SLC6A2ADRA1A | |
| SCHEMBL11138508 | 0.77 | LMNA (0.59) | TRPA1LMNACHRM1SLC6A2ADRA1A | |
| SCHEMBL24278905 | 0.74 | SRC (0.56) | TRPA1LMNACHRM1SLC6A2ADRA1A | |
| SCHEMBL16749880 | 0.74 | SRC (0.73) | TRPA1LMNACHRM1SLC6A2ADRA1A | |
| SCHEMBL10021098 | 0.73 | RIPK1 (0.58) | LMNARIPK1ALDH1A1 | |
| SCHEMBL9194021 | 0.72 | TRPA1 (0.68) | TRPA1LMNACHRM1SLC6A2ADRA1A | |
| SCHEMBL27599034 | 0.71 | TYR (0.45) | TRPA1LMNACHRM1SLC6A2ADRA1A | |
| SCHEMBL8238610 | 0.69 | LMNA (0.63) | TRPA1LMNACHRM1SLC6A2ADRA1A | |
| Thymol SCHEMBL28152803 | 0.69 | LMNA (0.91) | TRPA1LMNACHRM1SLC6A2ADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10751296-B2 | Curcuphenol compounds for increasing MHC-I expression | Cava Healthcare Inc. (CA) | 2020-08-25 | — | — | US | disclosed |
| US-20170319508-A1 | CURCUPHENOL COMPOUNDS FOR INCREASING MHC-I EXPRESSION | Cava Healthcare Inc. (CA) | 2017-11-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170319508-A1 | CURCUPHENOL COMPOUNDS FOR INCREASING MHC-I EXPRESSION | CD74, MICA, HLA-DRB1 | TRPA1 190/4885LMNA 3115/4885CHRM1 4177/4885 |
| US-10751296-B2 | Curcuphenol compounds for increasing MHC-I expression | CD74, MICA, HLA-DRB1 | TRPA1 190/4885LMNA 3115/4885CHRM1 4177/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.