SCHEMBL16757828

SCHEMBL16757828

FC(F)(F)C(F)(F)CN1CCC(COc2cnc(Br)cn2)CC1

nearest known ligand 0.36

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
DCPS Q96C86 1/20 0.36
LIPE Q05469 1/20 0.35
GPR119 Q8TDV5 1/20 0.34
ACHE P22303 2/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16758161 0.81 CHRNB2 (0.48)
SCHEMBL13908099 0.77 EP300 (0.36) LIPEACHE
SCHEMBL16758171 0.75 SIGMAR1 (0.46)
SCHEMBL16757858 0.75 HPGDS (0.42) LIPEGPR119ACHE
SCHEMBL21043224 0.74 HPGDS (0.37) DCPSLIPEGPR119ACHE
SCHEMBL1103832 0.74 KDM1A (0.37)
SCHEMBL1109070 0.73 CDK2 (0.40) ACHE
SCHEMBL16758013 0.73 HPGDS (0.41) LIPEGPR119ACHE
SCHEMBL4055411 0.73 LIPE (0.41) LIPEGPR119ACHE
SCHEMBL15537922 0.72 LIPE (0.37) DCPSLIPEGPR119ACHE

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3074384-B1 AMIDE DERIVATIVES FOR GPR119 AGONIST CHONG KUN DANG PHARMACEUTICAL CORP (KR) 2019-05-22 EP disclosed
US-9776987-B2 Amide derivatives for GPR119 agonist CHONG KUN DANG PHARMACEUTICAL CORP (KR) 2017-10-03 US disclosed
US-20170129875-A1 AMIDE DERIVATIVES FOR GPR119 AGONIST CHONG KUN DANG PHARMACEUTICAL CORP. (KR) 2017-05-11 US disclosed
EP-3074384-A1 AMIDE DERIVATIVES FOR GPR119 AGONIST Chong Kun Dang Pharmaceutical Corp. (KR) 2016-10-05 EP disclosed
WO-2015080446-A1 AMIDE DERIVATIVES FOR GPR119 AGONIST CHONG KUN DANG PHARMACEUTICAL CORP. (KR) 2015-06-04 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20170129875-A1 AMIDE DERIVATIVES FOR GPR119 AGONIST GPR119, FFAR2, GLP1R DCPS 3294/4885LIPE 495/4885GPR119 1/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.