SCHEMBL167767

SCHEMBL167767

O=C(O)Oc1ncc(F)cc1F

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
AGBL2 Q5U5Z8 1/20 0.39
SSTR4 P31391 1/20 0.38
HCAR2 Q8TDS4 1/20 0.37
KDM4E B2RXH2 1/20 0.35
ASPH Q12797 1/20 0.35
KDM8 Q8N371 1/20 0.35
PTGER4 P35408 3/20 0.33
HDAC3 O15379 1/20 0.33
HDAC1 Q13547 1/20 0.33
HDAC2 Q92769 1/20 0.33
HDAC6 Q9UBN7 1/20 0.33
KMO O15229 2/20 0.32
CES2 O00748 2/20 0.31
CES1 P23141 2/20 0.31
HSD11B1 P28845 2/20 0.31
GSK3A P49840 1/20 0.31
GSK3B P49841 1/20 0.31
GAA P10253 1/20 0.31
KMT2A Q03164 1/20 0.31
P2RY1 P47900 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4940831 0.83 SSTR4 (0.40) AGBL2SSTR4HCAR2PTGER4HDAC3
SCHEMBL8566221 0.83 AGBL2 (0.38) AGBL2SSTR4HCAR2KDM4EASPH
SCHEMBL28782994 0.81 SSTR4 (0.41) AGBL2SSTR4PTGER4HDAC3HDAC1
SCHEMBL28782995 0.81 AGBL2 (0.41) AGBL2SSTR4HCAR2KDM4EASPH
SCHEMBL12093598 0.71 PIK3CA (0.44) SSTR4
SCHEMBL107357 0.69 HCAR2 (0.45) AGBL2HCAR2KDM4EASPHKDM8
SCHEMBL15639062 0.69 PDK2 (0.35) AGBL2
SCHEMBL19546521 0.69 CES2 (0.41) HCAR2CES2CES1GAAKMT2A
SCHEMBL8807901 0.67 TRPA1 (0.51)
SCHEMBL1881949 0.67 POLB (0.42) AGBL2HCAR2KDM4EASPHKDM8

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2802587-B1 SUBSTITUTED, ANNELLATED IMIDAZOLES AND PYRAZOLES AND THEIR USE BAYER IP GMBH (DE) 2017-09-06 EP disclosed
EP-2611802-B1 BICYCLIC AZA-HETEROCYCLES AND THEIR USE BAYER IP GMBH (DE) 2016-02-24 EP disclosed
EP-2635576-B1 BENZYL-SUBSTITUTED CARBAMATES AND USE THEREOF BAYER IP GMBH (DE) 2015-02-25 EP disclosed
EP-2802587-A2 SUBSTITUTED, ANNULATED IMIDAZOLES AND PYRAZOLES, AND USE THEREOF Bayer Intellectual Property GmbH (DE) 2014-11-19 EP disclosed
EP-2635577-B1 SUBSTITUTED 6-FLUORO-1H-PYRAZOLO[4,3-B]PYRIDINES AND USE THEREOF BAYER IP GMBH (DE) 2014-10-01 EP disclosed
EP-2635577-A1 SUBSTITUTED 6-FLUORO-1H-PYRAZOLO[4,3-B]PYRIDINES AND USE THEREOF Bayer Intellectual Property GmbH (DE) 2013-09-11 EP disclosed
EP-2635576-A1 BENZYL-SUBSTITUTED CARBAMATES AND USE THEREOF Bayer Intellectual Property GmbH (DE) 2013-09-11 EP disclosed
WO-2013104598-A2 SUBSTITUTED, ANNULATED IMIDAZOLES AND PYRAZOLES, AND USE THEREOF BAYER INTELLECTUAL PROPERTY GMBH (DE) 2013-07-18 WO disclosed
EP-2611802-A1 BICYCLIC AZA HETEROCYCLES, AND USE THEREOF Bayer Intellectual Property GmbH (DE) 2013-07-10 EP disclosed
WO-2012059548-A1 BENZYL-SUBSTITUTED CARBAMATES AND USE THEREOF BAYER PHARMA AKTIENGESELLSCHAFT (DE) 2012-05-10 WO disclosed
WO-2012059549-A1 SUBSTITUTED 6-FLUORO-1H-PYRAZOLO[4,3-B]PYRIDINES AND USE THEREOF BAYER PHARMA AKTIENGESELLSCHAFT (DE) 2012-05-10 WO disclosed
WO-2012028647-A1 BICYCLIC AZA HETEROCYCLES, AND USE THEREOF BAYER PHARMA AKTIENGESELLSCHAFT (DE) 2012-03-08 WO disclosed