Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 known ✓ | P23975 | 1/20 | 0.38 |
| ▸ | SLC6A4 known ✓ | P31645 | 1/20 | 0.38 |
| ▸ | SIGMAR1 known ✓ | Q99720 | 1/20 | 0.36 |
| ▸ | SLC18A3 | Q16572 | 3/20 | 0.47 |
| ▸ | G6PC1 | P35575 | 1/20 | 0.41 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.38 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 3/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | YTHDC1 | Q96MU7 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL19897108 | 1.00 | SLC18A3 (0.47) | SLC18A3G6PC1OPRM1CA2SLC6A2 | |
| Bromide SCHEMBL19897327 | 1.00 | SLC18A3 (0.47) | SLC18A3G6PC1OPRM1CA2SLC6A2 | |
| SCHEMBL2197649 | 0.98 | SLC18A3 (0.49) | SLC18A3G6PC1OPRM1CA2SLC6A2 | |
| SCHEMBL2936927 | 0.98 | SLC18A3 (0.49) | SLC18A3G6PC1OPRM1CA2SLC6A2 | |
| SCHEMBL490929 | 0.98 | SLC18A3 (0.49) | SLC18A3G6PC1OPRM1CA2SLC6A2 | |
| SCHEMBL29615873 | 0.98 | SLC18A3 (0.49) | SLC18A3G6PC1OPRM1CA2SLC6A2 | |
| Bromide SCHEMBL20398790 | 0.95 | SLC18A3 (0.46) | SLC18A3G6PC1OPRM1CA2SLC6A2 | |
| SCHEMBL25209581 | 0.82 | SLC18A3 (0.48) | SLC18A3G6PC1OPRM1CA2SLC6A2 | |
| SCHEMBL28811067 | 0.82 | SLC18A3 (0.44) | SLC18A3OPRM1SLC6A2SLC6A4OPRK1 | |
| SCHEMBL6431460 | 0.81 | SIGMAR1 (0.37) | SLC18A3SLC6A2SLC6A4MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11528906-B2 | Pyrrolidinones as herbicides | FMC CORPORATION (US) | 2022-12-20 | — | — | US | disclosed |
| US-20220132844-A1 | PYRROLIDINONES AS HERBICIDES | E. I. DU PONT DE NEMOURS AND COMPANY | 2022-05-05 | — | — | US | disclosed |
| US-11180453-B2 | Substituted cyclic amides and their use as herbicides | FMC CORPORATION (US) | 2021-11-23 | — | — | US | disclosed |
| US-10906873-B2 | Substituted cyclic amides as herbicides | FMC CORPORATION (US) | 2021-02-02 | — | — | US | disclosed |
| US-20200347017-A1 | SUBSTITUTED CYCLIC AMIDES AND THEIR USE AS HERBICIDES | FMC CORPORATION | 2020-11-05 | — | — | US | disclosed |
| US-10442807-B2 | Aryl substituted bicyclic compounds as herbicides | FMC CORPORATION (US) | 2019-10-15 | — | — | US | disclosed |
| US-10405547-B2 | Substituted cyclic amides as herbicides | FMC CORPORATION (US) | 2019-09-10 | — | — | US | disclosed |
| US-20180215760-A1 | ARYL SUBSTITUTED BICYCLIC COMPOUNDS AS HERBICIDES | FMC CORPORATION | 2018-08-02 | — | — | US | disclosed |
| US-20180141904-A1 | SUBSTITUTED CYCLIC AMIDES AS HERBICIDES | FMC CORPORATION | 2018-05-24 | — | — | US | disclosed |
| US-20180049437-A1 | SUBSTITUTED CYCLIC AMIDES AS HERBICIDES | E. I. DU PONT DE NEMOURS AND COMPANY | 2018-02-22 | — | — | US | disclosed |
| EP-3077374-A1 | PYRROLIDINONES AS HERBICIDES | E. I. du Pont de Nemours and Company (US) | 2016-10-12 | — | — | EP | disclosed |
| WO-2015084796-A1 | PYRROLIDINONES AS HERBICIDES | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 2015-06-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (10 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220132844-A1 | PYRROLIDINONES AS HERBICIDES | DDT, ARG1, PRMT1 | SLC6A2 3645/4885SLC6A4 3661/4885SIGMAR1 973/4885 |
| US-10906873-B2 | Substituted cyclic amides as herbicides | CHRM2, DDT, CYP1A1 | SLC6A2 2002/4885SLC6A4 2399/4885SIGMAR1 495/4885 |
| US-20180215760-A1 | ARYL SUBSTITUTED BICYCLIC COMPOUNDS AS HERBICIDES | CYP1B1, CYP1A1, CBR3 | SLC6A2 2273/4885SLC6A4 2334/4885SIGMAR1 427/4885 |
| US-11528906-B2 | Pyrrolidinones as herbicides | DDT, ARG1, PRMT1 | SLC6A2 3645/4885SLC6A4 3661/4885SIGMAR1 973/4885 |
| US-10405547-B2 | Substituted cyclic amides as herbicides | CYP1A1, CYP1B1, QSOX1 | SLC6A2 1865/4885SLC6A4 2103/4885SIGMAR1 540/4885 |
| US-10442807-B2 | Aryl substituted bicyclic compounds as herbicides | CYP1B1, CYP1A1, CBR3 | SLC6A2 2273/4885SLC6A4 2334/4885SIGMAR1 427/4885 |
| US-20200347017-A1 | SUBSTITUTED CYCLIC AMIDES AND THEIR USE AS HERBICIDES | NIT2, ARG1, CNPY2 | SLC6A2 1357/4885SLC6A4 2348/4885SIGMAR1 512/4885 |
| US-20180141904-A1 | SUBSTITUTED CYCLIC AMIDES AS HERBICIDES | CHRM2, DDT, CYP1A1 | SLC6A2 2002/4885SLC6A4 2399/4885SIGMAR1 495/4885 |
| US-11180453-B2 | Substituted cyclic amides and their use as herbicides | NIT2, ARG1, CNPY2 | SLC6A2 1357/4885SLC6A4 2348/4885SIGMAR1 512/4885 |
| US-20180049437-A1 | SUBSTITUTED CYCLIC AMIDES AS HERBICIDES | CYP1A1, CYP1B1, QSOX1 | SLC6A2 1865/4885SLC6A4 2103/4885SIGMAR1 540/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.