Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.59 |
| ▸ | MAOB | P27338 | 13/20 | 0.59 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.52 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.52 |
| ▸ | SYK | P43405 | 3/20 | 0.50 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23291160 | 0.87 | HRH1 (0.58) | PARP10KDM4EALDH1A1SMN1; SMN2MAOB | |
| SCHEMBL11610651 | 0.83 | MAOB (0.59) | PARP10KDM4EALDH1A1SMN1; SMN2MAOB | |
| SCHEMBL511292 | 0.83 | ALDH1A1 (0.59) | PARP10KDM4EALDH1A1SMN1; SMN2MAOB | |
| SCHEMBL30461991 | 0.83 | ALDH1A1 (0.59) | PARP10KDM4EALDH1A1SMN1; SMN2MAOB | |
| SCHEMBL1733690 | 0.83 | PARP10 (0.60) | PARP10KDM4EALDH1A1SMN1; SMN2MAOB | |
| SCHEMBL12310925 | 0.83 | ALDH1A1 (0.59) | PARP10KDM4EALDH1A1SMN1; SMN2MAOB | |
| SCHEMBL30361386 | 0.82 | PARP10 (0.64) | PARP10KDM4EALDH1A1SMN1; SMN2MAOB | |
| SCHEMBL3571325 | 0.82 | PARP10 (0.64) | PARP10KDM4EALDH1A1SMN1; SMN2MAOB | |
| Ammonia Solution, Strong SCHEMBL23291159 | 0.81 | ALDH1A1 (0.58) | PARP10KDM4EALDH1A1SMN1; SMN2MAOB | |
| SCHEMBL6445371 | 0.81 | KCNH2 (0.67) | PARP10KDM4EALDH1A1SMN1; SMN2MAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11795163-B2 | Compound for inhibiting nicotinamide phosphoribosyltransferase and composition containing same | CHECKMATE THERAPEUTICS INC. | 2023-10-24 | — | — | US | disclosed |
| US-11795163-B2 | Compound for inhibiting nicotinamide phosphoribosyltransferase and composition containing same | CHECKMATE THERAPEUTICS INC. | 2023-10-24 | — | — | US | disclosed |
| WO-2023148643-A1 | FUSED BICYCLIC HETEROCYCLYL COMPOUNDS AS USP1 INHIBITORS | AURIGENE ONCOLOGY LIMITED (IN) | 2023-08-10 | — | — | WO | disclosed |
| EP-3431472-B1 | NOVEL COMPOUND FOR INHIBITING NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE AND COMPOSITION CONTAINING SAME | CHECKMATE THERAPEUTICS INC (KR) | 2023-05-03 | — | — | EP | disclosed |
| US-20230010258-A1 | COMPOSITION FOR PREVENTING OR INHIBITING AXONAL DEGENERATION | CHECKMATE THERAPEUTICS INC. (KR) | 2023-01-12 | — | — | US | disclosed |
| US-11078195-B2 | Compound for inhibiting nicotinamide phosphoribosyltransferase and composition containing same | CHECKMATE THERAPEUTICS INC. | 2021-08-03 | — | — | US | disclosed |
| US-20210171513-A1 | NOVEL COMPOUND FOR INHIBITING NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE AND COMPOSITION CONTAINING SAME | CHECKMATE THERAPEUTICS INC. (KR) | 2021-06-10 | — | — | US | disclosed |
| US-20200247795-A1 | NOVEL COMPOUND FOR INHIBITING NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE AND COMPOSITION CONTAINING SAME | CHECKMATE THERAPEUTICS INC. (KR) | 2020-08-06 | — | — | US | disclosed |
| EP-3431472-A2 | NOVEL COMPOUND FOR INHIBITING NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE AND COMPOSITION CONTAINING SAME | Industry-Academic Cooperation Foundation Yonsei University (KR) | 2019-01-23 | — | — | EP | disclosed |
| WO-2017160116-A9 | NOVEL COMPOUND FOR INHIBITING NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE AND COMPOSITION CONTAINING SAME | 연세대학교 산학협력단 | 2017-11-30 | — | — | WO | disclosed |
| US-20110195999-A1 | NOVEL ANTIFUNGAL AGENT CONTAINING HETEROCYCLIC COMPOUND | NAKAMOTO KAZUTAKA | 2011-08-11 | — | — | US | disclosed |
| US-7932272-B2 | Antifungal agent containing heterocyclic compound | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2011-04-26 | — | — | US | disclosed |
| US-7932272-B2 | Antifungal agent containing heterocyclic compound | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2011-04-26 | — | — | US | disclosed |
| US-7932272-B2 | Antifungal agent containing heterocyclic compound | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2011-04-26 | — | — | US | disclosed |
| US-20090227799-A1 | Novel Antimalarial Agent Containing Heterocyclic Compound | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2009-09-10 | — | — | US | disclosed |
| US-20070105943-A1 | Novel antifungal agent containing heterocyclic compound | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2007-05-10 | — | — | US | disclosed |
| US-20070105943-A1 | Novel antifungal agent containing heterocyclic compound | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2007-05-10 | — | — | US | disclosed |
| US-20070105943-A1 | Novel antifungal agent containing heterocyclic compound | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2007-05-10 | — | — | US | disclosed |
| EP-1782811-A1 | NOVEL ANTIMALARIA AGENT CONTAINING HETEROCYCLIC COMPOUND | Eisai R&D Management Co., Ltd. (JP) | 2007-05-09 | — | — | EP | disclosed |
| EP-1669348-A1 | NOVEL ANTIFUNGAL AGENT COMPRISING HETEROCYCLIC COMPOUND | Eisai Co., Ltd. (JP) | 2006-06-14 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110195999-A1 | NOVEL ANTIFUNGAL AGENT CONTAINING HETEROCYCLIC COMPOUND | ERG28, CYP51A1, XPO1 | PARP10 3249/4885KDM4E 3112/4885ALDH1A1 1677/4885 |
| US-11078195-B2 | Compound for inhibiting nicotinamide phosphoribosyltransferase and composition containing same | NAMPT, NAPRT, NNT | PARP10 110/4885KDM4E 2598/4885ALDH1A1 1903/4885 |
| US-20090227799-A1 | Novel Antimalarial Agent Containing Heterocyclic Compound | XPO1, THPO, G6PD | PARP10 796/4885KDM4E 3022/4885ALDH1A1 1926/4885 |
| US-20200247795-A1 | NOVEL COMPOUND FOR INHIBITING NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE AND COMPOSITION CONTAINING SAME | NAMPT, NAPRT, NNMT | PARP10 90/4885KDM4E 2591/4885ALDH1A1 2533/4885 |
| US-20070105943-A1 | Novel antifungal agent containing heterocyclic compound | ERG28, DPM1, CYP51A1 | PARP10 3140/4885KDM4E 3245/4885ALDH1A1 1459/4885 |
| US-20230010258-A1 | COMPOSITION FOR PREVENTING OR INHIBITING AXONAL DEGENERATION | BDNF, GAP43, PRPH | PARP10 2246/4885KDM4E 4503/4885ALDH1A1 2290/4885 |
| US-20210171513-A1 | NOVEL COMPOUND FOR INHIBITING NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE AND COMPOSITION CONTAINING SAME | NAMPT, NAPRT, NNMT | PARP10 90/4885KDM4E 2591/4885ALDH1A1 2533/4885 |
| US-11795163-B2 | Compound for inhibiting nicotinamide phosphoribosyltransferase and composition containing same | NAMPT, NAPRT, NNT | PARP10 110/4885KDM4E 2598/4885ALDH1A1 1903/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.