Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX4 | Q99571 | 15/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | SCN4A | P35499 | 1/20 | 0.40 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.40 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.40 |
| ▸ | P2RX1 | P51575 | 5/20 | 0.36 |
| ▸ | P2RX3 | P56373 | 5/20 | 0.36 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.36 |
| ▸ | PTBP1 | P26599 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | ESR1 | P03372 | 1/20 | 0.34 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.34 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.34 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8911614 | 0.84 | LMNA (0.47) | P2RX4LMNATSHRMAPK1SCN4A | |
| SCHEMBL2738798 | 0.75 | P2RX4 (0.82) | P2RX4LMNATSHRMAPK1SCN4A | |
| SCHEMBL4046801 | 0.65 | HSD17B3 (0.58) | P2RX4P2RX1P2RX3P2RX7 | |
| SCHEMBL4046807 | 0.65 | HSD17B3 (0.58) | P2RX4P2RX1P2RX3P2RX7 | |
| SCHEMBL20353763 | 0.64 | LMNA (0.42) | P2RX4LMNATSHRMAPK1SCN4A | |
| SCHEMBL28264764 | 0.64 | P2RX4 (0.36) | P2RX4LMNATSHRMAPK1SCN4A | |
| SCHEMBL16131301 | 0.62 | P2RX4 (0.77) | P2RX4LMNATSHRMAPK1SCN4A | |
| SCHEMBL16131286 | 0.61 | P2RX4 (0.69) | P2RX4LMNATSHRMAPK1SCN4A | |
| SCHEMBL4971001 | 0.60 | LMNA (0.52) | P2RX4LMNATSHRMAPK1SCN4A | |
| SCHEMBL11088295 | 0.60 | P2RX4 (0.43) | P2RX4LMNATSHRMAPK1SCN4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2852678-B1 | TRAPPING REAGENTS FOR REACTIVE METABOLITES SCREENING | BIOGEN MA INC (US) | 2017-08-23 | — | — | EP | disclosed |
| US-20170183378-A1 | TRAPPING REAGENTS FOR REACTIVE METABOLITES SCREENING | BIOGEN MA INC. (US) | 2017-06-29 | — | — | US | disclosed |
| US-9581605-B2 | Trapping reagents for reactive metabolites screening | BIOGEN MA INC. (US) | 2017-02-28 | — | — | US | disclosed |
| US-20150168430-A1 | TRAPPING REAGENTS FOR REACTIVE METABOLITES SCREENING | BIOGEN IDEC MA INC. (US) | 2015-06-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170183378-A1 | TRAPPING REAGENTS FOR REACTIVE METABOLITES SCREENING | SQOR, TST, AKR7A2 | P2RX4 1320/4885LMNA 2548/4885TSHR 853/4885 |
| US-20150168430-A1 | TRAPPING REAGENTS FOR REACTIVE METABOLITES SCREENING | SQOR, TST, AKR7A2 | P2RX4 1138/4885LMNA 2785/4885TSHR 701/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.