Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | STING1 | Q86WV6 | 8/20 | 0.58 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.58 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.58 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.53 |
| ▸ | PNP | P00491 | 1/20 | 0.53 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.52 |
| ▸ | HINT1 | P49773 | 1/20 | 0.52 |
| ▸ | NT5E | P21589 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21162740 | 1.00 | STING1 (0.58) | STING1PDE3BPDE3AADORA3PNP | |
| SCHEMBL5571313 | 1.00 | STING1 (0.58) | STING1PDE3BPDE3AADORA3PNP | |
| SCHEMBL6551940 | 0.98 | STING1 (0.58) | STING1PDE3BPDE3AADORA3PNP | |
| SCHEMBL20673214 | 0.86 | ADORA3 (0.52) | STING1PDE3BPDE3AADORA3ADORA2A | |
| SCHEMBL19417833 | 0.84 | STING1 (0.52) | STING1PDE3BPDE3AADORA3HINT1 | |
| SCHEMBL24772604 | 0.83 | STING1 (0.49) | STING1PDE3BPDE3AADORA3PNP | |
| SCHEMBL23600855 | 0.81 | STING1 (0.56) | STING1ADORA3ADORA2A | |
| SCHEMBL18661220 | 0.81 | ADORA3 (0.47) | STING1PDE3BPDE3AADORA3ADORA2A | |
| SCHEMBL8885117 | 0.81 | PNP (0.60) | STING1PDE3BPDE3AADORA3PNP | |
| SCHEMBL7030275 | 0.80 | HINT1 (0.63) | PNPHINT1NT5E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9688715-B2 | Synthetic pGpG analogs, methods of preparation and methods of use | Temple University—Of the Commonwealth System of Higher Education (US) | 2017-06-27 | — | — | US | disclosed |
| US-20150175649-A1 | SYNTHETIC pGpG ANALOGS, METHODS OF PREPARATION AND METHODS OF USE | TEMPLE UNIVERSITY - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION | 2015-06-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150175649-A1 | SYNTHETIC pGpG ANALOGS, METHODS OF PREPARATION AND METHODS OF USE | MRPL21, PGLS, CFTR | STING1 2354/4885PDE3B 180/4885PDE3A 122/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.