Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 2/20 | 0.43 |
| ▸ | QPCT | Q16769 | 5/20 | 0.40 |
| ▸ | QPCTL | Q9NXS2 | 1/20 | 0.40 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.38 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.37 |
| ▸ | WNT3A | P56704 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | HTT | P42858 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | TRPM8 | Q7Z2W7 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | PARP1 | P09874 | 1/20 | 0.33 |
| ▸ | GPR6 | P46095 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.32 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.32 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1684122 | 0.78 | RIPK1 (0.43) | RIPK1TRPM8GABRA1GABRG2GABRB3 | |
| SCHEMBL1684143 | 0.76 | RIPK1 (0.42) | RIPK1KDM4EALDH1A1GABRA1GABRG2 | |
| SCHEMBL1684139 | 0.72 | TDO2 (0.40) | RIPK1TRPM8RAB9A | |
| SCHEMBL1684181 | 0.72 | MPO (0.42) | — | |
| SCHEMBL1684118 | 0.70 | TDO2 (0.36) | RIPK1HDAC3POLBTRPM8 | |
| SCHEMBL1684177 | 0.68 | RIPK1 (0.45) | RIPK1TRPM8 | |
| SCHEMBL40939 | 0.66 | KDM4E (0.49) | CTNNB1WNT3AHTTSMN1; SMN2KDM4E | |
| SCHEMBL2234661 | 0.65 | KDM4E (0.44) | CTNNB1WNT3AHTTSMN1; SMN2KDM4E | |
| SCHEMBL15078308 | 0.65 | KDM4E (0.44) | CTNNB1WNT3APOLBHTTSMN1; SMN2 | |
| SCHEMBL4783535 | 0.64 | TRPM8 (0.55) | RIPK1HDAC3TRPM8RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011041512-A2 | COMPOSITIONS AND METHODS FOR TREATING MLV-INFECTION, AND PREVENTING AND TREATING MLV-INITIATED DISEASES | EMORY UNIVERSITY (US) | 2011-04-07 | — | — | WO | disclosed |