Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | HTT | P42858 | 4/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.37 |
| ▸ | LMNA | P02545 | 3/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.36 |
| ▸ | CDK1 | P06493 | 1/20 | 0.36 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.36 |
| ▸ | GSK3A | P49840 | 1/20 | 0.36 |
| ▸ | GSK3B | P49841 | 1/20 | 0.36 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.36 |
| ▸ | SMO | Q99835 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12003383 | 0.81 | KDM4E (0.42) | KDM4EHTTMAPTL3MBTL1ALDH1A1 | |
| SCHEMBL9294526 | 0.70 | KDM4E (0.45) | KDM4ENPC1RAB9AALDH1A1HPGD | |
| SCHEMBL9294923 | 0.69 | PTGDR2 (0.38) | KDM4ENPC1RAB9AALDH1A1TSHR | |
| SCHEMBL15609847 | 0.69 | SMN1; SMN2 (0.40) | KDM4EMAPTNPC1RAB9AL3MBTL1 | |
| SCHEMBL15713858 | 0.69 | HTT (0.41) | KDM4EHTTMAPTL3MBTL1LMNA | |
| SCHEMBL22772166 | 0.69 | ALDH1A1 (0.44) | KDM4EHTTMAPTNPC1RAB9A | |
| SCHEMBL29850874 | 0.69 | ALDH1A1 (0.44) | KDM4EHTTMAPTNPC1RAB9A | |
| SCHEMBL15778047 | 0.67 | KDM5A (0.64) | HTTMAPTNPC1RAB9AKDM5A | |
| Isuzinaxib SCHEMBL12003400 | 0.67 | CYBB (0.48) | KDM4EHTTMAPTL3MBTL1ALDH1A1 | |
| Isuzinaxib SCHEMBL30527926 | 0.67 | CYBB (0.48) | KDM4EHTTMAPTL3MBTL1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2889032-B1 | COMPOSITION FOR PREVENTING OR TREATING KIDNEY DISEASE COMPRISING PYRAZOLE DERIVATIVE | UNIV EWHA IND COLLABORATION (KR) | 2019-05-08 | — | — | EP | disclosed |
| EP-2889032-B1 | COMPOSITION FOR PREVENTING OR TREATING KIDNEY DISEASE COMPRISING PYRAZOLE DERIVATIVE | UNIV EWHA IND COLLABORATION (KR) | 2019-05-08 | — | — | EP | disclosed |
| US-20150218125-A1 | COMPOSITION FOR PREVENTING OR TREATING KIDNEY DISEASE COMPRISING PYRAZOLE DERIVATIVE | EWHA UNIVERSITY-INDUSTRY COLLABORATION FOUNDATION (KR) | 2015-08-06 | — | — | US | disclosed |
| US-20150218125-A1 | COMPOSITION FOR PREVENTING OR TREATING KIDNEY DISEASE COMPRISING PYRAZOLE DERIVATIVE | EWHA UNIVERSITY-INDUSTRY COLLABORATION FOUNDATION (KR) | 2015-08-06 | — | — | US | disclosed |
| US-20150218125-A1 | COMPOSITION FOR PREVENTING OR TREATING KIDNEY DISEASE COMPRISING PYRAZOLE DERIVATIVE | EWHA UNIVERSITY-INDUSTRY COLLABORATION FOUNDATION (KR) | 2015-08-06 | — | — | US | disclosed |
| EP-2889032-A1 | COMPOSITION FOR PREVENTING OR TREATING KIDNEY DISEASE COMPRISING PYRAZOLE DERIVATIVE | Ewha University-Industry Collaboration Foundation (KR) | 2015-07-01 | — | — | EP | disclosed |
| EP-2889032-A1 | COMPOSITION FOR PREVENTING OR TREATING KIDNEY DISEASE COMPRISING PYRAZOLE DERIVATIVE | Ewha University-Industry Collaboration Foundation (KR) | 2015-07-01 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150218125-A1 | COMPOSITION FOR PREVENTING OR TREATING KIDNEY DISEASE COMPRISING PYRAZOLE DERIVATIVE | REN, GLS, ATP6V1B1 | KDM4E 1980/4885HTT 4077/4885MAPT 3687/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.