Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | TACR1 | P25103 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 3/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | CKS1B | P61024 | 3/20 | 0.39 |
| ▸ | SKP1 | P63208 | 3/20 | 0.39 |
| ▸ | SKP2 | Q13309 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | DRD2 | P14416 | 1/20 | 0.39 |
| ▸ | DRD3 | P35462 | 1/20 | 0.39 |
| ▸ | CNR1 | P21554 | 1/20 | 0.39 |
| ▸ | ITGB2 | P05107 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1686088 | 0.89 | CKS1B (0.54) | METCKS1BSKP1SKP2GBA1 | |
| SCHEMBL1686127 | 0.83 | ACVR1 (0.45) | KDM4ETP53TSHRMEN1KMT2A | |
| SCHEMBL1686083 | 0.83 | MET (0.45) | METKDM4EALDH1A1TSHRTACR1 | |
| SCHEMBL1686085 | 0.75 | CKS1B (0.55) | METCKS1BSKP1SKP2GBA1 | |
| SCHEMBL1686108 | 0.73 | CKS1B (0.52) | METCKS1BSKP1SKP2GBA1 | |
| SCHEMBL1686112 | 0.70 | GFER (0.43) | METALDH1A1TSHRHSD17B10TACR1 | |
| SCHEMBL1686109 | 0.69 | CKS1B (0.50) | CKS1BSKP1SKP2GBA1 | |
| SCHEMBL4574031 | 0.69 | OGA (0.47) | KDM4EALDH1A1TSHRHSD17B10HPGD | |
| SCHEMBL4438731 | 0.68 | ALDH1A1 (0.44) | KDM4EALDH1A1TP53TSHRHSD17B10 | |
| SCHEMBL1686089 | 0.67 | SLC6A9 (0.38) | METALDH1A1DRD2DRD3CNR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2307374-A1 | PIPERAZIN-1-YL-TRIFLUOROMETHYL-SUBSTITUTED-PYRIDINES AS FAST DISSOCIATING DOPAMINE 2 RECEPTOR ANTAGONISTS | Janssen Pharmaceutica, N.V. (BE) | 2011-04-13 | — | — | EP | disclosed |
| WO-2010012758-A1 | PIPERAZIN-1-YL-TRIFLUOROMETHYL-SUBSTITUTED-PYRIDINES AS FAST DISSOCIATING DOPAMINE 2 RECEPTOR ANTAGONISTS | JANSSEN PHARMACEUTICA NV (BE) | 2010-02-04 | — | — | WO | disclosed |