Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.44 |
| ▸ | CSNK1D | P48730 | 3/20 | 0.44 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.44 |
| ▸ | LMNA | P02545 | 3/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | SLC6A7 | Q99884 | 3/20 | 0.41 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | CKS1B | P61024 | 5/20 | 0.41 |
| ▸ | SKP1 | P63208 | 5/20 | 0.41 |
| ▸ | SKP2 | Q13309 | 5/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | GRM5 | P41594 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2954119 | 0.83 | CKS1B (0.57) | ALDH1A1CKS1BSKP1SKP2MAPT | |
| SCHEMBL4443137 | 0.81 | ALDH1A1 (0.42) | ALDH1A1CSNK1DMAPK14LMNATSHR | |
| SCHEMBL5010343 | 0.80 | CSNK1D (0.67) | ALDH1A1CSNK1DMAPK14LMNATSHR | |
| SCHEMBL5457675 | 0.79 | HTT (0.54) | ALDH1A1CSNK1DMAPK14LMNATSHR | |
| SCHEMBL27764680 | 0.78 | CSNK1D (0.41) | ALDH1A1CSNK1DMAPK14LMNATSHR | |
| SCHEMBL1686083 | 0.78 | MET (0.45) | ALDH1A1LMNATSHRSLC6A7KDM4E | |
| SCHEMBL20523650 | 0.74 | KMT2A (0.47) | ALDH1A1LMNASLC6A7L3MBTL1MAPT | |
| SCHEMBL2927334 | 0.72 | LMNA (0.63) | LMNAHTT | |
| SCHEMBL4443140 | 0.71 | KDM4E (0.41) | ALDH1A1CSNK1DMAPK14LMNASLC6A7 | |
| SCHEMBL3442387 | 0.70 | ALDH1A1 (0.56) | ALDH1A1LMNATSHRSLC6A7KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2121630-A1 | FAST DISSOCIATING DOPAMINE 2 RECEPTOR ANTAGONISTS | Janssen Pharmaceutica, N.V. (BE) | 2009-11-25 | — | — | EP | disclosed |
| WO-2008098892-A1 | FAST DISSOCIATING DOPAMINE 2 RECEPTOR ANTAGONISTS | JANSSEN PHARMACEUTICA N.V. (BE) | 2008-08-21 | — | — | WO | disclosed |