Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | LMNA | P02545 | 4/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | TACR1 | P25103 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | GBA1 | P04062 | 4/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.39 |
| ▸ | DRD2 | P14416 | 1/20 | 0.39 |
| ▸ | DRD3 | P35462 | 1/20 | 0.39 |
| ▸ | CKS1B | P61024 | 3/20 | 0.38 |
| ▸ | SKP1 | P63208 | 3/20 | 0.38 |
| ▸ | SKP2 | Q13309 | 3/20 | 0.38 |
| ▸ | SLC6A7 | Q99884 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1686085 | 0.86 | CKS1B (0.55) | METGBA1CKS1BSKP1SKP2 | |
| SCHEMBL1686071 | 0.83 | MET (0.46) | METALDH1A1LMNAKDM4ETACR1 | |
| SCHEMBL7947101 | 0.82 | ADRB2 (0.52) | ALDH1A1LMNAKDM4ENPSR1 | |
| SCHEMBL27818825 | 0.81 | IDO1 (0.39) | METALDH1A1LMNAKDM4EHTT | |
| SCHEMBL4438731 | 0.78 | ALDH1A1 (0.44) | ALDH1A1LMNAKDM4EHPGDHTT | |
| SCHEMBL1686072 | 0.74 | ADRB2 (0.60) | LMNAKDM4EHTTGBA1MAPT | |
| SCHEMBL1686088 | 0.73 | CKS1B (0.54) | METGBA1CKS1BSKP1SKP2 | |
| SCHEMBL1579261 | 0.72 | IDO1 (0.50) | METALDH1A1LMNAKDM4EHPGD | |
| SCHEMBL1686108 | 0.71 | CKS1B (0.52) | METGBA1CKS1BSKP1SKP2 | |
| SCHEMBL1686112 | 0.70 | GFER (0.43) | METALDH1A1LMNATACR1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102171189-B | Piperazin-1-yl-trifluoromethyl-substituted-pyridines as fast dissociating dopamine 2 receptor antagonists | JANSSEN PHARMACEUTICA NV | 2013-11-20 | — | — | CN | disclosed |
| CN-102171189-A | Piperazin-1-yl-trifluoromethyl-substituted-pyridines as fast dissociating dopamine 2 receptor antagonists | JANSSEN PHARMACEUTICA NV | 2011-08-31 | — | — | CN | disclosed |
| EP-2307374-A1 | PIPERAZIN-1-YL-TRIFLUOROMETHYL-SUBSTITUTED-PYRIDINES AS FAST DISSOCIATING DOPAMINE 2 RECEPTOR ANTAGONISTS | Janssen Pharmaceutica, N.V. (BE) | 2011-04-13 | — | — | EP | disclosed |
| WO-2010012758-A1 | PIPERAZIN-1-YL-TRIFLUOROMETHYL-SUBSTITUTED-PYRIDINES AS FAST DISSOCIATING DOPAMINE 2 RECEPTOR ANTAGONISTS | JANSSEN PHARMACEUTICA NV (BE) | 2010-02-04 | — | — | WO | disclosed |