Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 9/20 | 0.47 |
| ▸ | HCAR3 | P49019 | 2/20 | 0.46 |
| ▸ | PTPN1 | P18031 | 6/20 | 0.44 |
| ▸ | HPGDS | O60760 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | NAMPT | P43490 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28111819 | 0.84 | HCAR3 (0.51) | HCAR3HPGDSKDM4EALDH1A1ALOX15 | |
| SCHEMBL18397134 | 0.83 | GBA1 (0.53) | GSK3BHCAR3PTPN1ALDH1A1 | |
| Hydrochloric Acid SCHEMBL9670823 | 0.81 | HCAR3 (0.45) | HCAR3HPGDSKDM4EALDH1A1ALOX15 | |
| SCHEMBL28865950 | 0.81 | HCAR3 (0.49) | HCAR3HPGDSKDM4EALDH1A1ALOX15 | |
| SCHEMBL12734188 | 0.80 | HCAR3 (0.49) | HCAR3HPGDSKDM4EALDH1A1ALOX15 | |
| SCHEMBL185127 | 0.78 | HCAR3 (0.65) | HCAR3KDM4EALDH1A1ALOX15HSD17B10 | |
| SCHEMBL18397143 | 0.77 | GSK3B (0.48) | GSK3BHCAR3PTPN1 | |
| SCHEMBL976946 | 0.77 | NNMT (0.55) | HCAR3HPGDSKDM4EALDH1A1ALOX15 | |
| SCHEMBL1778519 | 0.77 | HCAR3 (0.46) | HCAR3HPGDSKDM4EALDH1A1ALOX15 | |
| SCHEMBL641907 | 0.77 | GSK3B (0.57) | GSK3BPTPN1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9321790-B2 | Pyrimidinone derivatives as antimalarial agents | SANOFI (FR) | 2016-04-26 | — | — | US | disclosed |
| US-9321790-B2 | Pyrimidinone derivatives as antimalarial agents | SANOFI (FR) | 2016-04-26 | — | — | US | disclosed |
| US-20150183804-A1 | Pyrimidinone Derivatives as Antimalarial Agents | SANOFI (FR) | 2015-07-02 | — | — | US | disclosed |
| US-20150183804-A1 | Pyrimidinone Derivatives as Antimalarial Agents | SANOFI (FR) | 2015-07-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150183804-A1 | Pyrimidinone Derivatives as Antimalarial Agents | DHFR, PRMT1, PRMT7 | GSK3B 4087/4885HCAR3 4490/4885PTPN1 2798/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.