SCHEMBL641907

SCHEMBL641907

Cc1ccc(C(=O)CBr)cn1

nearest known ligand 0.57

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
GSK3B P49841 9/20 0.57
HDAC1 Q13547 1/20 0.55
HDAC6 Q9UBN7 1/20 0.55
KDM4E B2RXH2 1/20 0.49
PTPN1 P18031 6/20 0.48
KMT2A Q03164 2/20 0.42
MAPT P10636 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2632670 0.82 HDAC1 (0.56) HDAC1HDAC6KDM4EKMT2AMAPT
SCHEMBL13706438 0.81 HDAC1 (0.55) GSK3BHDAC1HDAC6KDM4EKMT2A
SCHEMBL14683904 0.81 HDAC1 (0.55) HDAC1HDAC6KDM4EKMT2AMAPT
SCHEMBL15136337 0.81 HDAC1 (0.55) HDAC1HDAC6KDM4EKMT2AMAPT
SCHEMBL15920457 0.81 HDAC1 (0.55) GSK3BHDAC1HDAC6KDM4EKMT2A
Hydrochloric Acid SCHEMBL3231047 0.79 HDAC1 (0.53) HDAC1HDAC6KDM4EKMT2AMAPT
SCHEMBL10812902 0.79 HDAC1 (0.58) HDAC1HDAC6KDM4EKMT2AMAPT
Hydrochloric Acid SCHEMBL9672401 0.79 HDAC1 (0.53) HDAC1HDAC6KDM4EKMT2AMAPT
SCHEMBL27386679 0.79 HSD17B3 (0.53) HDAC1HDAC6KDM4EKMT2AMAPT
SCHEMBL16601153 0.78 PTPN1 (0.55) GSK3BPTPN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 50 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12503477-B2 Colony stimulating factor-1 receptor (CSF-1R) inhibitors GENZYME CORPORATION 2025-12-23 US disclosed
US-20240217991-A1 COLONY STIMULATING FACTOR-1 RECEPTOR (CSF-1R) INHIBITORS GENZYME CORPORATION (US) 2024-07-04 US disclosed
US-11584742-B2 Substituted aminothiazoles as inhibitors of nucleases MASARYKOVA UNIVERZITA (CZ) 2023-02-21 US disclosed
US-20220411388-A1 SUBSTITUTED IMIDAZOLE CARBOXAMIDES AND THEIR USE IN THE TREATMENT OF MEDICAL DISORDERS BIAL R&D INVEST S A (PT) 2022-12-29 US disclosed
US-20220396588-A1 COLONY STIMULATING FACTOR-1 RECEPTOR (CSF-1R) INHIBITORS GENZYME CORPORATION (US) 2022-12-15 US disclosed
CN-107922396-B Colony stimulating factor-1 receptor (CSF-1R) inhibitors 建新公司 2022-08-05 CN disclosed
EP-4031531-A1 SUBSTITUTED IMIDAZOLE CARBOXAMIDES AND THEIR USE IN THE TREATMENT OF MEDICAL DISORDERS Bial-R&D Investments, S.A. (PT) 2022-07-27 EP disclosed
CN-114787135-A Substituted imidazole carboxamides and their use in the treatment of medical disorders 比亚尔R&D投资股份公司 2022-07-22 CN disclosed
US-11274108-B2 Colony stimulating factor-1 receptor (CSF-1R) inhibitors GENZYME CORPORATION (US) 2022-03-15 US disclosed
US-20220002282-A1 SUBSTITUTED AMINOTHIAZOLES AS INHIBITORS OF NUCLEASES MASARYKOVA UNIVERZITA (CZ) 2022-01-06 US disclosed
US-20130196967-A1 HETEROCYCLIC COMPOUNDS AS INHIBITORS OF LEUKOTRIENE PRODUCTION BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2013-08-01 US disclosed
US-20130196967-A1 HETEROCYCLIC COMPOUNDS AS INHIBITORS OF LEUKOTRIENE PRODUCTION BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2013-08-01 US disclosed
US-20130018048-A1 OXAZOLE DERIVATIVES USEFUL AS MODULATORS OF FAAH MERCK SHARP & DOHME CORP. (US) 2013-01-17 US disclosed
US-20120323002-A1 IMIDAZOPYRIDAZINE COMPOUNDS AJINOMOTO CO., INC. (JP) 2012-12-20 US disclosed
EP-2518072-A1 IMIDAZOPYRIDAZINE COMPOUNDS AJINOMOTO CO., INC. (JP) 2012-10-31 EP disclosed
US-20120214788-A1 HETEROARYL-SUBSTITUTED PIPERIDINES BAYER PHARMA AKTIENGESELLSCHAFT (DE) 2012-08-23 US disclosed
US-8119663-B2 Heteroaryl-substituted piperidines BAYER PHARMA AKTIENGESELLSCHAFT (DE) 2012-02-21 US disclosed
WO-2011126960-A1 OXAZOLE DERIVATIVES USEFUL AS MODULATORS OF FAAH MERCK SHARP & DOHME CORP. (US) 2011-10-13 WO disclosed
EP-2227466-B1 HETEROARYL-SUBSTITUTED PIPERIDINES BAYER SCHERING PHARMA AG (DE) 2011-04-20 EP disclosed
US-20090306139-A1 HETEROARYL-SUBSTITUTED PIPERIDINES BAYER HEALTHCARE AG (DE) 2009-12-10 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (12 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11584742-B2 Substituted aminothiazoles as inhibitors of nucleases RNASEH1, DNASE1, FEN1 GSK3B 3281/4885HDAC1 871/4885HDAC6 2355/4885
US-11274108-B2 Colony stimulating factor-1 receptor (CSF-1R) inhibitors CSF1R, CSF3R, IL1RN GSK3B 3571/4885HDAC1 713/4885HDAC6 1338/4885
US-20130018048-A1 OXAZOLE DERIVATIVES USEFUL AS MODULATORS OF FAAH FAAH, FAAH2, ALOX5 GSK3B 973/4885HDAC1 804/4885HDAC6 833/4885
US-20090306139-A1 HETEROARYL-SUBSTITUTED PIPERIDINES VHL, PIGO, PLIN3 GSK3B 4125/4885HDAC1 736/4885HDAC6 927/4885
US-20130196967-A1 HETEROCYCLIC COMPOUNDS AS INHIBITORS OF LEUKOTRIENE PRODUCTION LTB4R, LTC4S, LTB4R2 GSK3B 4498/4885HDAC1 1895/4885HDAC6 3615/4885
US-20240217991-A1 COLONY STIMULATING FACTOR-1 RECEPTOR (CSF-1R) INHIBITORS CSF1R, CSF3R, IL1RN GSK3B 3571/4885HDAC1 713/4885HDAC6 1338/4885
US-20120323002-A1 IMIDAZOPYRIDAZINE COMPOUNDS IL23R, IL15, IL5 GSK3B 639/4885HDAC1 106/4885HDAC6 77/4885
US-20220002282-A1 SUBSTITUTED AMINOTHIAZOLES AS INHIBITORS OF NUCLEASES RNASEH1, DNASE1, FEN1 GSK3B 3281/4885HDAC1 871/4885HDAC6 2355/4885
US-20220396588-A1 COLONY STIMULATING FACTOR-1 RECEPTOR (CSF-1R) INHIBITORS CSF1R, CSF3R, IL1RN GSK3B 3571/4885HDAC1 713/4885HDAC6 1338/4885
US-20220411388-A1 SUBSTITUTED IMIDAZOLE CARBOXAMIDES AND THEIR USE IN THE TREATMENT OF MEDICAL DISORDERS GBA1, GAA, CLN6 GSK3B 3304/4885HDAC1 107/4885HDAC6 12/4885
US-12503477-B2 Colony stimulating factor-1 receptor (CSF-1R) inhibitors CSF1R, CSF3R, IL1RN GSK3B 3153/4885HDAC1 678/4885HDAC6 1010/4885
US-20120214788-A1 HETEROARYL-SUBSTITUTED PIPERIDINES VHL, PIGO, PLIN3 GSK3B 4125/4885HDAC1 736/4885HDAC6 927/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.