Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.51 |
| ▸ | ACP3 | P15309 | 4/20 | 0.44 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.43 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | APAF1 | O14727 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ASPH | Q12797 | 1/20 | 0.40 |
| ▸ | KDM8 | Q8N371 | 1/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16871126 | 1.00 | KMT2A (0.51) | KMT2AACP3PTGS1PTGS2ALDH1A1 | |
| SCHEMBL8430344 | 0.85 | APAF1 (0.49) | KMT2AACP3ALDH1A1HPGDHSD17B10 | |
| SCHEMBL8829781 | 0.85 | APAF1 (0.49) | KMT2AACP3ALDH1A1HPGDHSD17B10 | |
| SCHEMBL28772271 | 0.81 | KMT2A (0.56) | KMT2APTGS1PTGS2ALDH1A1MEN1 | |
| SCHEMBL13380255 | 0.80 | KMT2A (0.55) | KMT2APTGS1PTGS2ALDH1A1HPGD | |
| SCHEMBL4677216 | 0.80 | KMT2A (0.58) | KMT2AACP3PTGS1PTGS2ALDH1A1 | |
| SCHEMBL4677219 | 0.80 | KMT2A (0.58) | KMT2AACP3PTGS1PTGS2ALDH1A1 | |
| SCHEMBL31477299 | 0.79 | KMT2A (0.53) | KMT2APTGS1PTGS2ALDH1A1HPGD | |
| SCHEMBL7626977 | 0.79 | KMT2A (0.53) | KMT2APTGS1PTGS2ALDH1A1MEN1 | |
| SCHEMBL19419826 | 0.78 | KMT2A (0.60) | KMT2APTGS1PTGS2ALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9346853-B2 | Synthesis of telaprevir and boceprevir, or pharmaceutically acceptable salts or solvates as well as intermediate products thereof including β-amino acids prepared via Mukaiyama aldol addition | SANDOZ AG (CH) | 2016-05-24 | — | — | US | disclosed |
| US-20150183824-A1 | SYNTHESIS OF TELAPREVIR AND BOCEPREVIR, OR PHARMACEUTICALLY ACCEPTABLE SALTS OR SOLVATES AS WELL AS INTERMEDIATE PRODUCTS THEREOF INCLUDING beta-AMINO ACIDS PREPARED VIA MUKAIYAMA ALDOL ADDITION | SANDOZ AG (CH) | 2015-07-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150183824-A1 | SYNTHESIS OF TELAPREVIR AND BOCEPREVIR, OR PHARMACEUTICALLY ACCEPTABLE SALTS OR SOLVATES AS WELL AS INTERMEDIATE PRODUCTS THEREOF INCLUDING beta-AMINO ACIDS PREPARED VIA MUKAIYAMA ALDOL ADDITION | MME, AGT, ACE | KMT2A 3110/4885ACP3 3451/4885PTGS1 1925/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.