SCHEMBL1689593

SCHEMBL1689593

O=C1OC2(c3cc(Cl)c(O)cc3Oc3cc(O)c(Cl)cc32)c2c(Cl)ccc(Cl)c21

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 4/20 0.44
HPGD P15428 3/20 0.44
HSD17B10 Q99714 3/20 0.44
BRCA1 P38398 2/20 0.44
CYP2C9 P11712 1/20 0.44
ALOX15 P16050 1/20 0.44
ALOX12 P18054 1/20 0.44
SMAD3 P84022 2/20 0.42
DHFR P00374 5/20 0.40
TYMS P04818 3/20 0.40
TDP1 Q9NUW8 4/20 0.38
RECQL P46063 3/20 0.38
THRB P10828 2/20 0.38
MEN1 O00255 2/20 0.38
BLM P54132 2/20 0.38
KMT2A Q03164 2/20 0.38
CYP3A4 P08684 2/20 0.38
TSHR P16473 2/20 0.38
MAPK1 P28482 1/20 0.38
CASP1 P29466 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1643388 0.84 HPGD (0.40) ALDH1A1HPGDHSD17B10BRCA1CYP2C9
SCHEMBL1444923 0.84 SMAD3 (0.57) ALDH1A1HPGDHSD17B10BRCA1CYP2C9
SCHEMBL79627 0.84 HPGD (0.63) ALDH1A1HPGDHSD17B10BRCA1CYP2C9
SCHEMBL12488503 0.83 HPGD (0.51) ALDH1A1HPGDHSD17B10BRCA1CYP2C9
SCHEMBL29461682 0.80 SMAD3 (0.40) ALDH1A1HPGDHSD17B10BRCA1CYP2C9
SCHEMBL235829 0.80 SMAD3 (0.40) ALDH1A1HPGDHSD17B10BRCA1CYP2C9
SCHEMBL1022908 0.80 SMAD3 (0.40) ALDH1A1HPGDHSD17B10BRCA1CYP2C9
SCHEMBL19211134 0.80 DHFR (0.47) ALDH1A1HPGDHSD17B10BRCA1CYP2C9
SCHEMBL1463198 0.79 SMAD3 (0.56) ALDH1A1HPGDHSD17B10BRCA1CYP2C9
SCHEMBL1468956 0.79 ALDH1A1 (0.40) ALDH1A1HPGDHSD17B10BRCA1CYP2C9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9587271-B2 Mixtures for assaying nucleic acid, novel method of assaying nucleic acid with the use of the same and nucleic acid probe to be used therefor NIPPON STEEL & SUMIKIN ECO-TECH CORPORATION (JP) 2017-03-07 US claimed
EP-3180464-A1 DETECTION OF NUCLEIC ACIDS The Regents of The University of Michigan (US) 2017-06-21 EP disclosed
US-9587271-B2 Mixtures for assaying nucleic acid, novel method of assaying nucleic acid with the use of the same and nucleic acid probe to be used therefor NIPPON STEEL & SUMIKIN ECO-TECH CORPORATION (JP) 2017-03-07 US disclosed
WO-2016025477-A1 DETECTION OF NUCLEIC ACIDS THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) 2016-02-18 WO disclosed
US-8469519-B2 Projection apparatus providing reduced speckle artifacts EASTMAN KODAK COMPANY (US) 2013-06-25 US disclosed
US-8218235-B2 Projection display surface providing artifact reduction EASTMAN KODAK COMPANY (US) 2012-07-10 US disclosed
US-20120008200-A1 PROJECTION DISPLAY SURFACE PROVIDING ARTIFACT REDUCTION IMAX CORPORATION (CA) 2012-01-12 US disclosed
US-8085467-B1 Projection display surface providing speckle reduction EASTMAN KODAK COMPANY (US) 2011-12-27 US disclosed
WO-2006132588-A1 METHOD FOR THE PURIFICATION OF SYNTHETIC OLIGONUCLEOTIDES CONTAINING ONE OR SEVERAL LABELS QUIATECH AB (SE) 2006-12-14 WO disclosed
WO-2005063787-A2 PROPARGYL SUBSTITUTED NUCLEOSIDE COMPOUNDS AND METHODS APPLERA CORPORATION (US) 2005-07-14 WO disclosed