Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMAD3 | P84022 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.40 |
| ▸ | HPGD | P15428 | 4/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.40 |
| ▸ | BRCA1 | P38398 | 2/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.40 |
| ▸ | RECQL | P46063 | 3/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | THRB | P10828 | 2/20 | 0.38 |
| ▸ | BLM | P54132 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | CASP1 | P29466 | 1/20 | 0.38 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.38 |
| ▸ | GLB1 | P16278 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29461682 | 0.91 | SMAD3 (0.40) | SMAD3ALDH1A1HPGDHSD17B10BRCA1 | |
| SCHEMBL235829 | 0.91 | SMAD3 (0.40) | SMAD3ALDH1A1HPGDHSD17B10BRCA1 | |
| Cyanide SCHEMBL6533545 | 0.88 | SMAD3 (0.38) | SMAD3ALDH1A1HPGDHSD17B10BRCA1 | |
| SCHEMBL5958386 | 0.87 | SMAD3 (0.36) | SMAD3ALDH1A1HPGDHSD17B10BRCA1 | |
| SCHEMBL5665945 | 0.85 | ALDH1A1 (0.58) | SMAD3ALDH1A1HPGDHSD17B10BRCA1 | |
| SCHEMBL6045753 | 0.83 | ALDH1A1 (0.47) | SMAD3ALDH1A1HPGDHSD17B10BRCA1 | |
| SCHEMBL1444923 | 0.83 | SMAD3 (0.57) | SMAD3ALDH1A1HPGDHSD17B10BRCA1 | |
| SCHEMBL1468956 | 0.82 | ALDH1A1 (0.40) | SMAD3ALDH1A1HPGDHSD17B10BRCA1 | |
| SCHEMBL204164 | 0.81 | ALDH1A1 (0.48) | SMAD3ALDH1A1HPGDHSD17B10BRCA1 | |
| SCHEMBL1689593 | 0.80 | ALDH1A1 (0.44) | SMAD3ALDH1A1HPGDHSD17B10BRCA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 60 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9110075-B2 | Compositions for analyzing proteins | MONOGRAM BIOSCIENCES, INC. (US) | 2015-08-18 | — | — | US | claimed |
| US-20130122506-A1 | NUCLEIC ACID BASE ANALOGS WITH QUENCHING AND FLUORESCENT ACTIVITIES AND APPLICATIONS THEREOF | TAGCYX BIOTECHNOLOGIES C/O RIKEN (JP) | 2013-05-16 | — | — | US | claimed |
| EP-2562255-A1 | NUCLEIC ACID BASE ANALOG WITH QUENCHING CHARACTERISTICS AND FLUORESCENCE AND APPLICATION THEREOF | Riken (JP) | 2013-02-27 | — | — | EP | claimed |
| US-8212014-B2 | Artificial base pairs and uses thereof | RIKEN (JP) | 2012-07-03 | — | — | US | claimed |
| US-7960543-B2 | Nucleoside or nucleotide derivative and use thereof | RIKEN (JP) | 2011-06-14 | — | — | US | claimed |
| US-20100285598-A1 | Novel Artificial Base Pairs and Uses Thereof | RIKEN (JP) | 2010-11-11 | — | — | US | claimed |
| US-20090275017-A1 | Novel Nucleoside or Nucleotide Derivative and Use Thereof | RIKEN (JP) | 2009-11-05 | — | — | US | claimed |
| EP-1921141-A1 | NOVEL ARTIFICIAL BASE PAIR AND USE THEREOF | Riken (JP) | 2008-05-14 | — | — | EP | claimed |
| EP-1816130-A1 | NOVEL NUCLEOSIDE OR NUCLEOTIDE DERIVATIVE AND USE THEREOF | Riken (JP) | 2007-08-08 | — | — | EP | claimed |
| EP-3180464-A1 | DETECTION OF NUCLEIC ACIDS | The Regents of The University of Michigan (US) | 2017-06-21 | — | — | EP | disclosed |
| US-9285319-B2 | Nucleic acid base analogs with quenching and fluorescent activities and applications thereof | RIKEN (JP) | 2016-03-15 | — | — | US | disclosed |
| WO-2016025477-A1 | DETECTION OF NUCLEIC ACIDS | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2016-02-18 | — | — | WO | disclosed |
| US-8835625-B2 | Propargyl substituted nucleoside compounds and methods | APPLIED BIOSYSTEMS, LLC (US) | 2014-09-16 | — | — | US | disclosed |
| US-20130122506-A1 | NUCLEIC ACID BASE ANALOGS WITH QUENCHING AND FLUORESCENT ACTIVITIES AND APPLICATIONS THEREOF | TAGCYX BIOTECHNOLOGIES C/O RIKEN (JP) | 2013-05-16 | — | — | US | disclosed |
| EP-1537230-A1 | FLUORESCENT ENZYME ASSAY METHODS AND COMPOSITIONS | Applera Corporation (US) | 2005-06-08 | — | — | EP | disclosed |
| US-20040146959-A1 | Fluorescent enzyme assay methods and compositions | APPLIED BIOSYSTEMS, LLC | 2004-07-29 | — | — | US | disclosed |
| US-20040106120-A1 | Diagnosis and treatment of disease | AVLARBIOVENTURES LIMITED AS MANAGER OF AVLAR BIOVENTURES FUND II LIMITED PARTNERSHIP AND SITKA HEALTH FUND VCT PLC (GB) | 2004-06-03 | — | — | US | disclosed |
| WO-2004022773-A1 | FLUORESCENT ENZYME ASSAY METHODS AND COMPOSITIONS | APPLERA CORPORATION (US) | 2004-03-18 | — | — | WO | disclosed |
| EP-1356298-A2 | DIAGNOSIS AND TREATMENT OF DISEASE | Molecular Skincare Limited (GB) | 2003-10-29 | — | — | EP | disclosed |
| WO-2002044736-A2 | DIAGNOSIS AND TREATMENT OF EPIDERMAL OR SKIN DISEASES | MOLECULAR SKINCARE LIMITED (GB) | 2002-06-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090275017-A1 | Novel Nucleoside or Nucleotide Derivative and Use Thereof | DUT, NT5C3B, NT5C | SMAD3 1901/4885ALDH1A1 2280/4885HPGD 735/4885 |
| US-20100285598-A1 | Novel Artificial Base Pairs and Uses Thereof | POLRMT, RNGTT, POLN | SMAD3 4583/4885ALDH1A1 3557/4885HPGD 3654/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.