Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Milveterol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB2 known ✓ | P07550 | 19/20 | 1.00 |
| ▸ | ADRB1 | P08588 | 5/20 | 1.00 |
| ▸ | ADRB3 | P13945 | 4/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Milveterol SCHEMBL265695 | 1.00 | ADRB2 (1.00) | ADRB2ADRB1ADRB3 | |
| Milveterol SCHEMBL4385046 | 1.00 | ADRB2 (1.00) | ADRB2ADRB1ADRB3 | |
| Milveterol SCHEMBL185356 | 1.00 | ADRB2 (1.00) | ADRB2ADRB1ADRB3 | |
| Milveterol SCHEMBL265694 | 1.00 | ADRB2 (1.00) | ADRB2ADRB1ADRB3 | |
| Milveterol SCHEMBL29448200 | 1.00 | ADRB2 (1.00) | ADRB2ADRB1ADRB3 | |
| Milveterol SCHEMBL2953766 | 0.99 | ADRB2 (0.98) | ADRB2ADRB1ADRB3 | |
| Milveterol SCHEMBL2953771 | 0.99 | ADRB2 (0.98) | ADRB2ADRB1ADRB3 | |
| Milveterol SCHEMBL2014102 | 0.99 | ADRB2 (0.98) | ADRB2ADRB1ADRB3 | |
| Milveterol SCHEMBL2014100 | 0.99 | ADRB2 (0.98) | ADRB2ADRB1ADRB3 | |
| Milveterol SCHEMBL2014099 | 0.99 | ADRB2 (0.98) | ADRB2ADRB1ADRB3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 573 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11247969-B2 | Biphenyl compounds useful as muscarinic receptor antagonists | THERAVANCE BIOPHARMA R&D IP, LLC (US) | 2022-02-15 | — | — | US | claimed |
| US-20200290966-A1 | BIPHENYL COMPOUNDS USEFUL AS MUSCARINIC RECEPTOR ANTAGONISTS | THERAVANCE BIOPHARMA R&D IP, LLC (US) | 2020-09-17 | — | — | US | claimed |
| US-20140288033-A1 | CRYSTALLINE FORMS OF A BIPHENYL COMPOUND | THERAVANCE, INC. (US) | 2014-09-25 | — | — | US | claimed |
| US-20130125887-A1 | CRYSTALLINE FORMS OF A BIPHENYL COMPOUND | THERAVANCE, INC. (US) | 2013-05-23 | — | — | US | claimed |
| US-7772434-B2 | Crystalline form of a β2 adrenergic receptor agonist | THERAVANCE, INC. (US) | 2010-08-10 | — | — | US | claimed |
| US-20100125150-A1 | CRYSTALLINE FORM OF A BETA2 ADRENERGIC RECEPTOR AGONIST | THERAVANCE, INC. (US) | 2010-05-20 | — | — | US | claimed |
| EP-1856050-B1 | CRYSTALLINE FORMS OF A BIPHENYL COMPOUND | THERAVANCE INC (US) | 2009-11-25 | — | — | EP | claimed |
| EP-1898894-A1 | MRP IV INHIBITORS FOR THE TREATMENT OF RESPIRATORY DISEASES | Boehringer Ingelheim International GmbH (DE) | 2008-03-19 | — | — | EP | claimed |
| EP-1893203-A2 | MEDICAMENT CONTAINING A BETAMIMETIC IN CONJUNCTION WITH AN ANTICHOLINERGIC AND A PDE IV INHIBITOR | Boehringer Ingelheim International GmbH (DE) | 2008-03-05 | — | — | EP | claimed |
| US-20070298112-A1 | salt of biphenyl-2-ylcarbamic acid 1-(2-{[4-(4-carbamoylpiperidin-1-ylmethyl)benzoyl]methylamino}ethyl)piperidin-4-yl ester and phosphoric acid; pulmonary disorders | THERAVANCE BIOPHARMA R&D IP, LLC | 2007-12-27 | — | — | US | claimed |
| WO-2006128847-A2 | MEDICAMENT CONTAINING A BETAMIMETIC IN CONJUNCTION WITH AN ANTICHOLINERGIC AND A PDE IV INHIBITOR | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2006-12-07 | — | — | WO | claimed |
| US-20060270667-A1 | NOVEL MEDICAMENT COMBINATIONS FOR THE TREATMENT OF RESPIRATORY DISEASES | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2006-11-30 | — | — | US | claimed |
| EP-1641744-A2 | CRYSTALLINE FORM OF B2 ADRENERGIC RECEPTOR AGONIST | Theravance, Inc. (US) | 2006-04-05 | — | — | EP | claimed |
| WO-2006018391-A1 | INHALATORY MEDICAMENTS CONTAINING CORTICOSTEROIDS, BETAMIMETIC AGENTS, AND A NOVEL ANTICHOLINERGENIC AGENT | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2006-02-23 | — | — | WO | claimed |
| US-20060034776-A1 | Inhalable medicaments containing a new anticholinergic, corticosteroids, and betamimetics | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2006-02-16 | — | — | US | claimed |
| WO-2005123670-A2 | CRYSTALLINE FORM OF A SUBSTITUTED PYRROLIDINE COMPOUND | THERAVANCE, INC. (US) | 2005-12-29 | — | — | WO | claimed |
| US-20050277688-A1 | Crystalline form of a substituted pyrrolidine compound | THERAVANCE, INC. | 2005-12-15 | — | — | US | claimed |
| US-20050075271-A1 | Crystalline beta2 adrenergic receptor agonist | THERAVANCE, INC. | 2005-04-07 | — | — | US | claimed |
| WO-2004106279-A2 | CRYSTALLINE FORM OF β2 ADRENERGIC RECEPTOR AGONIST | THERAVANCE, INC. (US) | 2004-12-09 | — | — | WO | claimed |
| US-20040248985-A1 | Crystalline form of beta2 adrenergic receptor agonist | THERAVANCE BIOPHARMA R&D IP, LLC | 2004-12-09 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (11 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060270667-A1 | NOVEL MEDICAMENT COMBINATIONS FOR THE TREATMENT OF RESPIRATORY DISEASES | ADRB3, CHRM3, ADRB2 | ADRB2 3/4885ADRB1 5/4885ADRB3 1/4885 |
| US-11247969-B2 | Biphenyl compounds useful as muscarinic receptor antagonists | CHRM2, CHRM1, CHRM3 | ADRB2 14/4885ADRB1 7/4885ADRB3 13/4885 |
| US-20050277688-A1 | Crystalline form of a substituted pyrrolidine compound | PKD2, H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16, PKD1 | ADRB2 3122/4885ADRB1 3252/4885ADRB3 3374/4885 |
| US-20130125887-A1 | CRYSTALLINE FORMS OF A BIPHENYL COMPOUND | FFAR1, FFAR4, FFAR3 | ADRB2 2730/4885ADRB1 1439/4885ADRB3 2164/4885 |
| US-20070298112-A1 | salt of biphenyl-2-ylcarbamic acid 1-(2-{[4-(4-carbamoylpiperidin-1-ylmethyl)benzoyl]methylamino}ethyl)piperidin-4-yl ester and phosphoric acid; pulmonary disorders | PLCB1, SLC20A1, SLC34A1 | ADRB2 1968/4885ADRB1 1122/4885ADRB3 2555/4885 |
| US-20060034776-A1 | Inhalable medicaments containing a new anticholinergic, corticosteroids, and betamimetics | ADRB1, ADRB2, ADRB3 | ADRB2 2/4885ADRB1 1/4885ADRB3 3/4885 |
| US-20040248985-A1 | Crystalline form of beta2 adrenergic receptor agonist | ADRB2, ADRA2C, ADRA2A | ADRB2 1/4885ADRB1 4/4885ADRB3 6/4885 |
| US-20140288033-A1 | CRYSTALLINE FORMS OF A BIPHENYL COMPOUND | FFAR1, FFAR4, FFAR3 | ADRB2 2730/4885ADRB1 1439/4885ADRB3 2164/4885 |
| US-20200290966-A1 | BIPHENYL COMPOUNDS USEFUL AS MUSCARINIC RECEPTOR ANTAGONISTS | CHRM2, CHRM1, CHRM3 | ADRB2 14/4885ADRB1 7/4885ADRB3 13/4885 |
| US-20100125150-A1 | CRYSTALLINE FORM OF A BETA2 ADRENERGIC RECEPTOR AGONIST | ADRB2, ADRA2C, ADRA2A | ADRB2 1/4885ADRB1 4/4885ADRB3 7/4885 |
| US-20050075271-A1 | Crystalline beta2 adrenergic receptor agonist | ADRB2, ADRA2C, ADRA2A | ADRB2 1/4885ADRB1 4/4885ADRB3 7/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.