Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 1/20 | 0.47 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.46 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.46 |
| ▸ | KDM1A | O60341 | 1/20 | 0.42 |
| ▸ | PTGS2 | P35354 | 4/20 | 0.41 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | CYP11B2 | P19099 | 4/20 | 0.40 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.38 |
| ▸ | NSD2 | O96028 | 1/20 | 0.38 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.38 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.38 |
| ▸ | RORC | P51449 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15810308 | 0.86 | AR (0.47) | KIF11PDE3BPDE3AKDM1A | |
| SCHEMBL397141 | 0.86 | KIF11 (0.61) | KIF11PDE3BPDE3APTGS1CYP11B2 | |
| SCHEMBL91862 | 0.85 | ALDH1A1 (0.53) | KIF11PDE3BPDE3AKDM1ACYP11B2 | |
| SCHEMBL91992 | 0.85 | ALDH1A1 (0.53) | KIF11PDE3BPDE3AKDM1ACYP11B2 | |
| SCHEMBL16941052 | 0.85 | KIF11 (0.43) | KIF11PDE3BPDE3AKDM1APTGS1 | |
| SCHEMBL16945932 | 0.84 | PTGS2 (0.47) | KIF11PDE3BPDE3AKDM1APTGS2 | |
| SCHEMBL26555703 | 0.83 | CYP11B2 (0.44) | KIF11KDM1ATP53CYP11B2CYP11B1 | |
| SCHEMBL19912967 | 0.82 | PTGS2 (0.50) | PDE3BPDE3APTGS2PTGS1AKR1C3 | |
| SCHEMBL10304732 | 0.82 | KIF11 (0.50) | KIF11TP53CYP11B2ALDH1A1CYP2A6 | |
| SCHEMBL16941059 | 0.82 | PDE3B (0.40) | KIF11PDE3BPDE3AKDM1ACYP11B2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9644144-B2 | Bimesogenic compounds and mesogenic media | MERCK PATENT GMBH (DE) | 2017-05-09 | — | — | US | disclosed |
| US-20160229795-A1 | COMPOUNDS AND MESOGENIC MEDIA | MERCK PATENT GMBH (DE) | 2016-08-11 | — | — | US | disclosed |
| US-20160222293-A1 | MESOGENIC COMPOUNDS AND MESOGENIC MEDIA | MERCK PATENT GMBH (DE) | 2016-08-04 | — | — | US | disclosed |
| US-20150315470-A1 | BIMESOGENIC COMPOUNDS AND MESOGENIC MEDIA | MERCK PATENT GMBH (DE) | 2015-11-05 | — | — | US | disclosed |
| US-20150210921-A1 | BIMESOGENIC COMPOUNDS AND MESOGENIC MEDIA | MERCK PATENT GMBH (DE) | 2015-07-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160229795-A1 | COMPOUNDS AND MESOGENIC MEDIA | MTX1, NEFM, MTX2 | KIF11 512/4885PDE3B 1993/4885PDE3A 1715/4885 |
| US-20150210921-A1 | BIMESOGENIC COMPOUNDS AND MESOGENIC MEDIA | SP1, FOXM1, S100A11 | KIF11 30/4885PDE3B 4695/4885PDE3A 4738/4885 |
| US-20150315470-A1 | BIMESOGENIC COMPOUNDS AND MESOGENIC MEDIA | SP1, FOXM1, S100A11 | KIF11 30/4885PDE3B 4695/4885PDE3A 4738/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.