Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Levomenthol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPM8 known ✓ | Q7Z2W7 | 5/20 | 0.66 |
| ▸ | TRPA1 known ✓ | O75762 | 2/20 | 0.66 |
| ▸ | EPHX1 | P07099 | 3/20 | 0.45 |
| ▸ | TRPV1 | Q8NER1 | 6/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Menthol SCHEMBL1695587 | 1.00 | TRPM8 (0.66) | TRPM8TRPA1EPHX1TRPV1 | |
| (+)-Menthol SCHEMBL11526858 | 0.85 | TRPM8 (0.72) | TRPM8TRPA1EPHX1TRPV1 | |
| Menthol SCHEMBL11526862 | 0.85 | TRPM8 (0.72) | TRPM8TRPA1EPHX1TRPV1 | |
| Menthol SCHEMBL6129363 | 0.85 | TRPM8 (0.72) | TRPM8TRPA1EPHX1TRPV1 | |
| Menthol SCHEMBL3817833 | 0.84 | TRPA1 (0.60) | TRPM8TRPA1EPHX1 | |
| Menthol SCHEMBL320045 | 0.83 | TRPM8 (0.75) | TRPM8TRPA1EPHX1TRPV1 | |
| Menthol SCHEMBL27677630 | 0.83 | TRPM8 (0.75) | TRPM8TRPA1EPHX1TRPV1 | |
| Menthol SCHEMBL117884 | 0.83 | TRPM8 (0.88) | TRPM8TRPA1EPHX1TRPV1 | |
| Levomenthol SCHEMBL2954662 | 0.83 | TRPM8 (0.88) | TRPM8TRPA1EPHX1TRPV1 | |
| Menthol SCHEMBL28455572 | 0.81 | TRPM8 (0.84) | TRPM8TRPA1EPHX1TRPV1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2585027-B1 | ENCAPSULATION OF INGREDIENTS IN LACTOSE MATRIX TO FORM ACTIVE ENCAPSULATES | COLGATE PALMOLIVE CO (US) | 2017-11-08 | — | — | EP | disclosed |
| EP-2585027-A1 | ENCAPSULATION OF INGREDIENTS IN LACTOSE MATRIX TO FORM ACTIVE ENCAPSULATES | Colgate-Palmolive Company (US) | 2013-05-01 | — | — | EP | disclosed |
| US-20130071456-A1 | ENCAPSULATION OF INGREDIENTS IN LACTOSE MATRIX TO FORM ACTIVE ENCAPSULATES | COLGATE-PALMOLIVE COMPANY (US) | 2013-03-21 | — | — | US | disclosed |
| WO-2011162755-A1 | ENCAPSULATION OF INGREDIENTS IN LACTOSE MATRIX TO FORM ACTIVE ENCAPSULATES | COLGATE-PALMOLIVE COMPANY (US) | 2011-12-29 | — | — | WO | disclosed |