Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Menthol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPA1 known ✓ | O75762 | 2/20 | 0.60 |
| ▸ | TRPM8 known ✓ | Q7Z2W7 | 2/20 | 0.60 |
| ▸ | EPHX1 | P07099 | 3/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7636456 | 0.93 | EPHX1 (0.57) | TRPA1TRPM8EPHX1ALDH1A1HPGD | |
| SCHEMBL12522387 | 0.93 | EPHX1 (0.57) | TRPA1TRPM8EPHX1ALDH1A1HPGD | |
| SCHEMBL15291348 | 0.93 | EPHX1 (0.57) | TRPA1TRPM8EPHX1ALDH1A1HPGD | |
| SCHEMBL12449351 | 0.93 | EPHX1 (0.57) | TRPA1TRPM8EPHX1ALDH1A1HPGD | |
| SCHEMBL471089 | 0.93 | EPHX1 (0.57) | TRPA1TRPM8EPHX1ALDH1A1HPGD | |
| SCHEMBL23196361 | 0.93 | EPHX1 (0.57) | TRPA1TRPM8EPHX1ALDH1A1HPGD | |
| SCHEMBL13430521 | 0.93 | EPHX1 (0.57) | TRPA1TRPM8EPHX1ALDH1A1HPGD | |
| SCHEMBL12449339 | 0.93 | EPHX1 (0.57) | TRPA1TRPM8EPHX1ALDH1A1HPGD | |
| SCHEMBL320044 | 0.93 | EPHX1 (0.57) | TRPA1TRPM8EPHX1ALDH1A1HPGD | |
| SCHEMBL15697973 | 0.93 | EPHX1 (0.57) | TRPA1TRPM8EPHX1ALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 70 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10835610-B2 | Pharmaceutical or cosmetic compositions comprising a polymer and an absorption promoter for controlled release of active ingredients | EMENEM s.r.l. (IT) | 2020-11-17 | — | — | US | claimed |
| US-20170239357-A1 | PHARMACEUTICAL OR COSMETIC COMPOSITIONS COMPRISING A POLYMER AND AN ABSORPTION PROMOTER FOR CONTROLLED RELEASE OF ACTIVE INGREDIENTS | EMENEM s.r.l. (IT) | 2017-08-24 | — | — | US | claimed |
| CN-104812732-A | Composition of menthol and menthyl lactate, its preparation and its use as a cooling, flavouring and/or fragrance agent | BASF SE | 2015-07-29 | — | — | CN | claimed |
| EP-1146852-B1 | A COSMETIC COMPOSITION BASED ON MENTHOL AND MENTHYL LACTATE, HAVING LITTLE ODOR AND BEING NON-IRRITATING | JOHNSON & JOHNSON CONSUMER FR (FR) | 2003-04-02 | — | — | EP | claimed |
| US-20020119110-A1 | For use as shower gel, foaming gel for face | JOHNSON & JOHNSON CONSUMER FRANCE SAS, ROC DIVISION (FR) | 2002-08-29 | — | — | US | claimed |
| CN-1337874-A | Cosmetic composition based on menthol and menthyl lactate, without odour and without irritation | JOHNSON & JOHNSON CONSUMER FR (FR) | 2002-02-27 | — | — | CN | claimed |
| EP-1146852-A1 | A COSMETIC COMPOSITION BASED ON MENTHOL AND MENTHYL LACTATE, HAVING LITTLE ODOR AND BEING NON-IRRITATING | Johnson & Johnson Consumer France (FR) | 2001-10-24 | — | — | EP | claimed |
| WO-2000042983-A1 | A COSMETIC COMPOSITION BASED ON MENTHOL AND MENTHYL LACTATE, HAVING LITTLE ODOR AND BEING NON-IRRITATING | JOHNSON & JOHNSON CONSUMER FRANCE (FR) | 2000-07-27 | — | — | WO | claimed |
| US-12478942-B2 | Methods of making capsules | THE PROCTER & GAMBLE COMPANY (US) | 2025-11-25 | — | — | US | disclosed |
| EP-3955890-B1 | CAPSULES | PROCTER & GAMBLE (US) | 2025-07-16 | — | — | EP | disclosed |
| US-12343696-B2 | Capsules | THE PROCTER & GAMBLE COMPANY (US) | 2025-07-01 | — | — | US | disclosed |
| CN-113660926-B | capsule | 宝洁公司 | 2025-03-07 | — | — | CN | disclosed |
| US-20240238748-A1 | CAPSULES | PROCTER & GAMBLE (US) | 2024-07-18 | — | — | US | disclosed |
| US-11904287-B2 | Capsules | THE PROCTER & GAMBLE COMPANY (US) | 2024-02-20 | — | — | US | disclosed |
| CN-1337874-A | Cosmetic composition based on menthol and menthyl lactate, without odour and without irritation | JOHNSON & JOHNSON CONSUMER FR (FR) | 2002-02-27 | — | — | CN | disclosed |
| CN-1337874-A | Cosmetic composition based on menthol and menthyl lactate, without odour and without irritation | JOHNSON & JOHNSON CONSUMER FR (FR) | 2002-02-27 | — | — | CN | disclosed |
| EP-1146852-A1 | A COSMETIC COMPOSITION BASED ON MENTHOL AND MENTHYL LACTATE, HAVING LITTLE ODOR AND BEING NON-IRRITATING | Johnson & Johnson Consumer France (FR) | 2001-10-24 | — | — | EP | disclosed |
| EP-1146852-A1 | A COSMETIC COMPOSITION BASED ON MENTHOL AND MENTHYL LACTATE, HAVING LITTLE ODOR AND BEING NON-IRRITATING | Johnson & Johnson Consumer France (FR) | 2001-10-24 | — | — | EP | disclosed |
| WO-2000042983-A1 | A COSMETIC COMPOSITION BASED ON MENTHOL AND MENTHYL LACTATE, HAVING LITTLE ODOR AND BEING NON-IRRITATING | JOHNSON & JOHNSON CONSUMER FRANCE (FR) | 2000-07-27 | — | — | WO | disclosed |
| WO-2000042983-A1 | A COSMETIC COMPOSITION BASED ON MENTHOL AND MENTHYL LACTATE, HAVING LITTLE ODOR AND BEING NON-IRRITATING | JOHNSON & JOHNSON CONSUMER FRANCE (FR) | 2000-07-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10835610-B2 | Pharmaceutical or cosmetic compositions comprising a polymer and an absorption promoter for controlled release of active ingredients | LIPA, MITF, CUTA | TRPA1 490/4885TRPM8 198/4885EPHX1 3372/4885 |
| US-20170239357-A1 | PHARMACEUTICAL OR COSMETIC COMPOSITIONS COMPRISING A POLYMER AND AN ABSORPTION PROMOTER FOR CONTROLLED RELEASE OF ACTIVE INGREDIENTS | LIPA, MITF, CUTA | TRPA1 490/4885TRPM8 198/4885EPHX1 3372/4885 |
| US-20020119110-A1 | For use as shower gel, foaming gel for face | LDHA, LDHB, ADH5 | TRPA1 192/4885TRPM8 28/4885EPHX1 1029/4885 |
| US-12478942-B2 | Methods of making capsules | FUT6, FUT5, LIPA | TRPA1 4829/4885TRPM8 4570/4885EPHX1 2355/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.