Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | HPGD | P15428 | 3/20 | 0.45 |
| ▸ | GSR | P00390 | 1/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | RORC | P51449 | 1/20 | 0.38 |
| ▸ | FEN1 | P39748 | 1/20 | 0.37 |
| ▸ | TGM2 | P21980 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.35 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8937915 | 0.83 | ALDH1A1 (0.52) | ALDH1A1HPGDGSRNPC1GLA | |
| SCHEMBL20275217 | 0.82 | ALDH1A1 (0.50) | ALDH1A1HPGDGSRSMN1; SMN2FEN1 | |
| SCHEMBL15570103 | 0.81 | CA12 (0.47) | ALDH1A1HPGDGSRNPC1SMN1; SMN2 | |
| SCHEMBL16981796 | 0.81 | ALDH1A1 (0.46) | ALDH1A1HPGDGSRNPC1GLA | |
| SCHEMBL976845 | 0.80 | ALDH1A1 (0.61) | ALDH1A1HPGDTHRBNPC1GLA | |
| SCHEMBL3967913 | 0.79 | THRB (0.42) | ALDH1A1HPGDTHRBSMN1; SMN2KMT2A | |
| SCHEMBL10932004 | 0.78 | THRB (0.41) | ALDH1A1THRBTGM2MEN1KMT2A | |
| SCHEMBL14492573 | 0.74 | ALDH1A1 (0.41) | ALDH1A1HPGDGSRSMN1; SMN2 | |
| SCHEMBL5183325 | 0.74 | ALDH1A1 (0.46) | ALDH1A1HPGDGSRNPC1SMN1; SMN2 | |
| Methacrylic Acid SCHEMBL15637610 | 0.73 | ALDH1A1 (0.64) | ALDH1A1HPGDGSRNPC1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2884981-B1 | 4-HETEROARYL SUBSTITUTED BENZOIC ACID COMPOUNDS AS RORgammaT INHIBITORS AND USES THEREOF | MERCK SHARP & DOHME (US) | 2018-06-20 | — | — | EP | disclosed |
| US-9745265-B2 | 4-heteroaryl substituted benzoic acid compounds as RORgammaT inhibitors and uses thereof | MERCK SHARP & DOHME CORP. (US) | 2017-08-29 | — | — | US | disclosed |
| US-20150218096-A1 | 4-HETEROARYL SUBSTITUTED BENZOIC ACID COMPOUNDS AS RORgammaT INHIBITORS AND USES THEREOF | MERCK SHARP & DOHME LLC | 2015-08-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150218096-A1 | 4-HETEROARYL SUBSTITUTED BENZOIC ACID COMPOUNDS AS RORgammaT INHIBITORS AND USES THEREOF | RORB, RORA, RORC | ALDH1A1 263/4885HPGD 1172/4885GSR 4460/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.