Sugi Predict

Sugi Predict / Compounds / SCHEMBL16985244

SCHEMBL16985244

SCHEMBL16985244

CS(=O)(=O)c1cc2c(F)cccc2o1

nearest known ligand 0.39

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
▸ MKNK1 Q9BUB5 1/20 0.38
▸ PTGS2 P35354 3/20 0.38
▸ NPC1 O15118 1/20 0.37
▸ HPGD P15428 1/20 0.37
▸ RAB9A P51151 1/20 0.37
▸ SMN1; SMN2 Q16637 1/20 0.37
▸ MEN1 O00255 2/20 0.35
▸ KMT2A Q03164 2/20 0.35
▸ CA2 P00918 2/20 0.35
▸ CCR2 P41597 1/20 0.34
▸ AR P10275 2/20 0.34
▸ F2RL3 Q96RI0 3/20 0.34
▸ PKM P14618 1/20 0.33
▸ PKLR P30613 1/20 0.33
▸ NMUR2 Q9GZQ4 1/20 0.33
▸ SLC9A1 P19634 1/20 0.33
▸ CA12 O43570 1/20 0.33
▸ CA1 P00915 1/20 0.33
▸ CA9 Q16790 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL18233459 0.83 NPC1 (0.37) MKNK1NPC1HPGDRAB9ASMN1; SMN2
SCHEMBL12278890 0.76 SMN1; SMN2 (0.38) NPC1HPGDRAB9ASMN1; SMN2KMT2A
SCHEMBL12728518 0.72 CYP1A1 (0.40) NPC1HPGDRAB9ASMN1; SMN2AR
SCHEMBL16985241 0.71 CA2 (0.67) HPGDRAB9ASMN1; SMN2CA2CCR2
SCHEMBL18536442 0.69 SMN1; SMN2 (0.37) NPC1HPGDRAB9ASMN1; SMN2AR
SCHEMBL18313612 0.69 ALDH1A1 (0.54) NPC1HPGDRAB9ASMN1; SMN2MEN1
SCHEMBL2097841 0.68 NPC1 (0.39) NPC1HPGDRAB9ASMN1; SMN2AR
SCHEMBL16686379 0.68 CYP2A6 (0.52) NPC1HPGDRAB9ASMN1; SMN2MEN1
SCHEMBL12967211 0.68 PDE4A (0.38) NPC1HPGDRAB9ASMN1; SMN2F2RL3
SCHEMBL12937261 0.68 F2RL3 (0.40) MKNK1NPC1HPGDRAB9ASMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-10626112-B2 Heterocyclic sulfonamide derivative and medicine comprising same EA PHARMA CO., LTD. (JP) 2020-04-21 — — US disclosed
US-20180162844-A1 CYCLOPROPANE DERIVATIVE AND DRUG CONTAINING SAME EA PHARMA CO., LTD. (JP) 2018-06-14 — — US disclosed
US-20180162844-A1 CYCLOPROPANE DERIVATIVE AND DRUG CONTAINING SAME EA PHARMA CO., LTD. (JP) 2018-06-14 — — US disclosed
US-20160332999-A1 HETEROCYCLIC SULFONAMIDE DERIVATIVE AND MEDICINE COMPRISING SAME EA PHARMA CO., LTD. (JP) 2016-11-17 — — US disclosed
US-20160332999-A1 HETEROCYCLIC SULFONAMIDE DERIVATIVE AND MEDICINE COMPRISING SAME EA PHARMA CO., LTD. (JP) 2016-11-17 — — US disclosed
WO-2015115507-A1 HETEROCYCLIC SULFONAMIDE DERIVATIVE AND MEDICINE COMPRISING SAME 味の素株式会社 2015-08-06 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20160332999-A1 HETEROCYCLIC SULFONAMIDE DERIVATIVE AND MEDICINE COMPRISING SAME TRPA1, TRPV1, TRPV2 MKNK1 3076/4885PTGS2 191/4885NPC1 705/4885
US-10626112-B2 Heterocyclic sulfonamide derivative and medicine comprising same TRPA1, TRPV1, TRPV2 MKNK1 3076/4885PTGS2 191/4885NPC1 705/4885
US-20180162844-A1 CYCLOPROPANE DERIVATIVE AND DRUG CONTAINING SAME TRPA1, TRPV1, TRPV2 MKNK1 3348/4885PTGS2 49/4885NPC1 419/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.