Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.35 |
| ▸ | GAA | P10253 | 3/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 3/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | MAP3K11 | Q16584 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.32 |
| ▸ | DRD1 | P21728 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 2/20 | 0.31 |
| ▸ | USP2 | O75604 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1699212 | 0.80 | MAP3K11 (0.40) | KDM4EGAAHSD17B10MAPK1MEN1 | |
| SCHEMBL1699242 | 0.80 | L3MBTL1 (0.56) | KDM4EGAAALDH1A1MAPTNPC1 | |
| SCHEMBL1699409 | 0.78 | ALDH1A1 (0.37) | KDM4EGAAHSD17B10MAPK1ATM | |
| SCHEMBL1699098 | 0.73 | DRD1 (0.44) | MEN1KMT2ADRD1LMNA | |
| SCHEMBL1699258 | 0.70 | L3MBTL1 (0.55) | ALDH1A1NPC1RAB9AL3MBTL1CSNK2A1 | |
| SCHEMBL1699291 | 0.69 | HSP90AA1 (0.40) | KDM4EGAAHSD17B10HPGDALDH1A1 | |
| SCHEMBL1699227 | 0.69 | MEN1 (0.44) | KDM4EGAAHSD17B10MAPK1MEN1 | |
| SCHEMBL1699234 | 0.65 | L3MBTL1 (0.54) | NPC1RAB9AL3MBTL1CSNK2A1LMNA | |
| SCHEMBL1699264 | 0.65 | MAP3K11 (0.40) | KDM4EGAAHSD17B10MAPK1MEN1 | |
| SCHEMBL1699349 | 0.65 | MAP3K11 (0.38) | KDM4EGAAHSD17B10MAPK1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2585462-A1 | FUSED HETEROCYCLIC COMPOUNDS AS PHOSPHODIESTERASES (PDES) INHIBITORS | Takeda Pharmaceutical Company Limited (JP) | 2013-05-01 | — | — | EP | disclosed |
| WO-2011163355-A1 | FUSED HETEROCYCLIC COMPOUNDS AS PHOSPHODIESTERASES (PDES) INHIBITORS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2011-12-29 | — | — | WO | disclosed |