Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 1/20 | 0.53 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.53 |
| ▸ | HSP90B1 | P14625 | 3/20 | 0.51 |
| ▸ | ADORA3 | P0DMS8 | 4/20 | 0.50 |
| ▸ | ADORA2B | P29275 | 4/20 | 0.50 |
| ▸ | ADORA2A | P29274 | 3/20 | 0.50 |
| ▸ | ADORA1 | P30542 | 3/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | DOT1L | Q8TEK3 | 2/20 | 0.50 |
| ▸ | DPP4 | P27487 | 1/20 | 0.50 |
| ▸ | EHMT1 | Q9H9B1 | 1/20 | 0.50 |
| ▸ | SLC28A1 | O00337 | 1/20 | 0.50 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.50 |
| ▸ | SLC28A2 | O43868 | 1/20 | 0.50 |
| ▸ | GAPDH | P04406 | 1/20 | 0.50 |
| ▸ | STAT6 | P42226 | 1/20 | 0.50 |
| ▸ | PI4KA | P42356 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16991503 | 0.84 | PRMT5 (0.58) | PRMT5WDR77HSP90B1ADORA3ADORA2B | |
| SCHEMBL16998222 | 0.84 | PRMT5 (0.58) | PRMT5WDR77HSP90B1ADORA3ADORA2B | |
| SCHEMBL16998062 | 0.84 | PRMT5 (0.58) | PRMT5WDR77HSP90B1ADORA3ADORA2B | |
| SCHEMBL16991506 | 0.84 | PRMT5 (0.58) | PRMT5WDR77HSP90B1ADORA3ADORA2B | |
| SCHEMBL19219141 | 0.84 | PRMT5 (0.57) | PRMT5WDR77HSP90B1ADORA3ADORA2B | |
| SCHEMBL16998142 | 0.82 | ADORA3 (0.54) | PRMT5WDR77HSP90B1ADORA3ADORA2B | |
| SCHEMBL17445618 | 0.81 | ADORA3 (0.55) | PRMT5WDR77HSP90B1ADORA3ADORA2B | |
| SCHEMBL18073288 | 0.80 | PRMT5 (0.56) | PRMT5WDR77HSP90B1ADORA3ADORA2B | |
| SCHEMBL12386685 | 0.80 | PRMT5 (0.56) | PRMT5WDR77HSP90B1ADORA3ADORA2B | |
| SCHEMBL16998321 | 0.79 | HINT1 (0.50) | ADORA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170296664-A1 | 4'-Difluoromethyl Substituted Nucleoside Derivatives as Inhibitors of Influenza RNA Replication | RIBOSCIENCE LLC | 2017-10-19 | — | — | US | disclosed |
| US-9370569-B2 | 4′-difluoromethyl substituted nucleoside derivatives as inhibitors of influenza RNA replication | RIBOSCIENCE LLC (US) | 2016-06-21 | — | — | US | disclosed |
| US-20150225441-A1 | 4'-Difluoromethyl Substituted Nucleoside Derivatives as Inhibitors of Influenza RNA Replication | RIBOSCIENCE LLC | 2015-08-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150225441-A1 | 4'-Difluoromethyl Substituted Nucleoside Derivatives as Inhibitors of Influenza RNA Replication | RNMT, DUT, RNGTT | PRMT5 1256/4885WDR77 1075/4885HSP90B1 3190/4885 |
| US-20170296664-A1 | 4'-Difluoromethyl Substituted Nucleoside Derivatives as Inhibitors of Influenza RNA Replication | RNMT, DUT, RNGTT | PRMT5 1256/4885WDR77 1075/4885HSP90B1 3190/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.