Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RY1 | P47900 | 10/20 | 0.50 |
| ▸ | P2RY2 | P41231 | 3/20 | 0.50 |
| ▸ | P2RX3 | P56373 | 3/20 | 0.50 |
| ▸ | ENPP1 | P22413 | 2/20 | 0.50 |
| ▸ | P2RX1 | P51575 | 2/20 | 0.50 |
| ▸ | P2RY11 | Q96G91 | 2/20 | 0.50 |
| ▸ | P2RY6 | Q15077 | 1/20 | 0.50 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.50 |
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.49 |
| ▸ | NT5E | P21589 | 1/20 | 0.49 |
| ▸ | RNASEL | Q05823 | 1/20 | 0.48 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.47 |
| ▸ | IMPDH1 | P20839 | 1/20 | 0.47 |
| ▸ | P2RX2 | Q9UBL9 | 1/20 | 0.47 |
| ▸ | GPR17 | Q13304 | 2/20 | 0.46 |
| ▸ | CA5A | P35218 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16998340 | 0.89 | P2RX1 (0.60) | P2RY1P2RY2P2RX3P2RX1P2RY11 | |
| SCHEMBL16998342 | 0.86 | TGM2 (0.53) | P2RY2P2RY6NT5E | |
| SCHEMBL16998343 | 0.81 | RNASEL (0.57) | P2RY1P2RY2P2RX3P2RX1P2RY11 | |
| SCHEMBL15678030 | 0.80 | P2RY1 (0.48) | P2RY1P2RY2P2RX3ENPP1P2RX1 | |
| SCHEMBL16998339 | 0.79 | POLG (0.52) | P2RY1P2RY2P2RY11P2RY6 | |
| SCHEMBL15678092 | 0.79 | P2RY1 (0.51) | P2RY1P2RY2P2RX3ENPP1P2RX1 | |
| SCHEMBL16998337 | 0.79 | POLG (0.42) | P2RY1P2RY2P2RY11P2RY6 | |
| SCHEMBL16998338 | 0.78 | POLG (0.50) | P2RY2P2RY6 | |
| SCHEMBL17860765 | 0.78 | POLG (0.50) | P2RY2P2RY6 | |
| SCHEMBL15678061 | 0.78 | P2RY1 (0.50) | P2RY1P2RY2P2RX3ENPP1P2RX1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4705313-A2 | 4'-SUBSTITUTED NUCLEOSIDES AND NUCLEOTIDES AS ANTIVIRAL AGENTS | The Scripps Research Institute (US) | 2026-03-11 | — | — | EP | claimed |
| WO-2024227159-A2 | 4'-SUBSTITUTED NUCLEOSIDES AND NUCLEOTIDES AS ANTIVIRAL AGENTS | THE SCRIPPS RESEARCH INSTITUTE (US) | 2024-10-31 | — | — | WO | claimed |
| EP-4705313-A2 | 4'-SUBSTITUTED NUCLEOSIDES AND NUCLEOTIDES AS ANTIVIRAL AGENTS | The Scripps Research Institute (US) | 2026-03-11 | — | — | EP | disclosed |
| WO-2024227159-A2 | 4'-SUBSTITUTED NUCLEOSIDES AND NUCLEOTIDES AS ANTIVIRAL AGENTS | THE SCRIPPS RESEARCH INSTITUTE (US) | 2024-10-31 | — | — | WO | disclosed |
| EP-3102215-B1 | 4'-DIFLUOROMETHYL SUBSTITUTED NUCLEOSIDE DERIVATIVES AS INHIBITORS OF INFLUENZA RNA REPLICATION | RIBOSCIENCE LLC (US) | 2021-06-16 | — | — | EP | disclosed |
| US-20170296664-A1 | 4'-Difluoromethyl Substituted Nucleoside Derivatives as Inhibitors of Influenza RNA Replication | RIBOSCIENCE LLC | 2017-10-19 | — | — | US | disclosed |
| US-20170296664-A1 | 4'-Difluoromethyl Substituted Nucleoside Derivatives as Inhibitors of Influenza RNA Replication | RIBOSCIENCE LLC | 2017-10-19 | — | — | US | disclosed |
| US-9370569-B2 | 4′-difluoromethyl substituted nucleoside derivatives as inhibitors of influenza RNA replication | RIBOSCIENCE LLC (US) | 2016-06-21 | — | — | US | disclosed |
| US-9370569-B2 | 4′-difluoromethyl substituted nucleoside derivatives as inhibitors of influenza RNA replication | RIBOSCIENCE LLC (US) | 2016-06-21 | — | — | US | disclosed |
| WO-2015120237-A2 | 4'-DIFLUOROMETHYL SUBSTITUTED NUCLEOSIDE DERIVATIVES AS INHIBITORS OF INFLUENZA RNA REPLICATION | RIBOSCIENCE LLC (US) | 2015-08-13 | — | — | WO | disclosed |
| US-20150225441-A1 | 4'-Difluoromethyl Substituted Nucleoside Derivatives as Inhibitors of Influenza RNA Replication | RIBOSCIENCE LLC | 2015-08-13 | — | — | US | disclosed |
| US-20150225441-A1 | 4'-Difluoromethyl Substituted Nucleoside Derivatives as Inhibitors of Influenza RNA Replication | RIBOSCIENCE LLC | 2015-08-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150225441-A1 | 4'-Difluoromethyl Substituted Nucleoside Derivatives as Inhibitors of Influenza RNA Replication | RNMT, DUT, RNGTT | P2RY1 282/4885P2RY2 662/4885P2RX3 612/4885 |
| US-20170296664-A1 | 4'-Difluoromethyl Substituted Nucleoside Derivatives as Inhibitors of Influenza RNA Replication | RNMT, DUT, RNGTT | P2RY1 282/4885P2RY2 662/4885P2RX3 612/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.