Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGM2 | P21980 | 1/20 | 0.53 |
| ▸ | POLG | P54098 | 2/20 | 0.51 |
| ▸ | KRAS | P01116 | 5/20 | 0.50 |
| ▸ | NT5E | P21589 | 1/20 | 0.50 |
| ▸ | FUT5 | Q11128 | 1/20 | 0.49 |
| ▸ | PNP | P00491 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 2/20 | 0.48 |
| ▸ | P2RY2 | P41231 | 1/20 | 0.47 |
| ▸ | P2RY4 | P51582 | 1/20 | 0.47 |
| ▸ | P2RY6 | Q15077 | 1/20 | 0.47 |
| ▸ | DCPS | Q96C86 | 1/20 | 0.45 |
| ▸ | POLA1 | P09884 | 1/20 | 0.44 |
| ▸ | STING1 | Q86WV6 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15678087 | 0.88 | POLG (0.49) | TGM2POLGKRASNT5EFUT5 | |
| SCHEMBL15828230 | 0.88 | TGM2 (0.55) | TGM2POLGKRASNT5EFUT5 | |
| SCHEMBL15828308 | 0.88 | TGM2 (0.55) | TGM2POLGKRASNT5EFUT5 | |
| SCHEMBL19590349 | 0.87 | TGM2 (0.55) | TGM2POLGKRASNT5EFUT5 | |
| SCHEMBL16368368 | 0.86 | FUT5 (0.55) | TGM2POLGKRASNT5EFUT5 | |
| SCHEMBL14929137 | 0.86 | FUT5 (0.55) | TGM2POLGKRASNT5EFUT5 | |
| SCHEMBL14946278 | 0.86 | FUT5 (0.55) | TGM2POLGKRASNT5EFUT5 | |
| SCHEMBL18573811 | 0.86 | FUT5 (0.55) | TGM2POLGKRASNT5EFUT5 | |
| SCHEMBL18573812 | 0.86 | FUT5 (0.55) | TGM2POLGKRASNT5EFUT5 | |
| SCHEMBL16998341 | 0.86 | P2RY1 (0.50) | NT5EP2RY2P2RY6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170296664-A1 | 4'-Difluoromethyl Substituted Nucleoside Derivatives as Inhibitors of Influenza RNA Replication | RIBOSCIENCE LLC | 2017-10-19 | — | — | US | disclosed |
| US-20170296664-A1 | 4'-Difluoromethyl Substituted Nucleoside Derivatives as Inhibitors of Influenza RNA Replication | RIBOSCIENCE LLC | 2017-10-19 | — | — | US | disclosed |
| US-9370569-B2 | 4′-difluoromethyl substituted nucleoside derivatives as inhibitors of influenza RNA replication | RIBOSCIENCE LLC (US) | 2016-06-21 | — | — | US | disclosed |
| US-9370569-B2 | 4′-difluoromethyl substituted nucleoside derivatives as inhibitors of influenza RNA replication | RIBOSCIENCE LLC (US) | 2016-06-21 | — | — | US | disclosed |
| US-20150225441-A1 | 4'-Difluoromethyl Substituted Nucleoside Derivatives as Inhibitors of Influenza RNA Replication | RIBOSCIENCE LLC | 2015-08-13 | — | — | US | disclosed |
| US-20150225441-A1 | 4'-Difluoromethyl Substituted Nucleoside Derivatives as Inhibitors of Influenza RNA Replication | RIBOSCIENCE LLC | 2015-08-13 | — | — | US | disclosed |
| WO-2015120237-A2 | 4'-DIFLUOROMETHYL SUBSTITUTED NUCLEOSIDE DERIVATIVES AS INHIBITORS OF INFLUENZA RNA REPLICATION | RIBOSCIENCE LLC (US) | 2015-08-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150225441-A1 | 4'-Difluoromethyl Substituted Nucleoside Derivatives as Inhibitors of Influenza RNA Replication | RNMT, DUT, RNGTT | TGM2 2935/4885POLG 138/4885KRAS 873/4885 |
| US-20170296664-A1 | 4'-Difluoromethyl Substituted Nucleoside Derivatives as Inhibitors of Influenza RNA Replication | RNMT, DUT, RNGTT | TGM2 2935/4885POLG 138/4885KRAS 873/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.