Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS3 | P29474 | 1/20 | 0.48 |
| ▸ | NOS1 | P29475 | 1/20 | 0.48 |
| ▸ | NOS2 | P35228 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.44 |
| ▸ | TSHR | P16473 | 6/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.44 |
| ▸ | RECQL | P46063 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.41 |
| ▸ | GABRP | O00591 | 1/20 | 0.40 |
| ▸ | GABRD | O14764 | 1/20 | 0.40 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.40 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.40 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.40 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.40 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.40 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.40 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.40 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.40 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.40 |
| ▸ | GABRE | P78334 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31129879 | 0.80 | S1PR4 (0.44) | ALDH1A1TSHRCYP3A4RECQLTDP1 | |
| SCHEMBL109187 | 0.79 | ALDH1A1 (0.41) | ALDH1A1TSHRCYP3A4TDP1GAA | |
| SCHEMBL30078658 | 0.79 | ALDH1A1 (0.41) | ALDH1A1TSHRCYP3A4TDP1GAA | |
| SCHEMBL799663 | 0.79 | ALDH1A1 (0.53) | ALDH1A1MAPT | |
| SCHEMBL1923229 | 0.76 | BACE1 (0.37) | ALDH1A1CYP3A4TDP1GABRPGABRD | |
| SCHEMBL10309700 | 0.76 | MAPT (0.40) | ALDH1A1TSHRCYP3A4RECQLTDP1 | |
| SCHEMBL31481290 | 0.76 | ALDH1A1 (0.39) | ALDH1A1TSHRCYP3A4RECQLTDP1 | |
| SCHEMBL15530461 | 0.73 | GABRP (0.55) | ALDH1A1TSHRCYP3A4TDP1GABRP | |
| SCHEMBL539616 | 0.72 | NOS3 (0.48) | NOS3NOS1NOS2ALDH1A1TSHR | |
| SCHEMBL30875970 | 0.72 | NOS3 (0.48) | NOS3NOS1NOS2ALDH1A1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2566849-B1 | 8-HYDROXY-QUINOLINE DERIVATIVES | AVIDIN KUTATO FEJLESZTOE ES KERESKEDELMI KORLATOLT FELELOESSEGUE TARSASAG (HU) | 2019-09-18 | — | — | EP | disclosed |
| CN-102985407-B | 8-hydroxy-quinoline derivatives | "AVIDIN" KUTATO, FEJLESZTO ES KERESKEDELMI KORLATOLT FELELOSSEGU TARSASAG (HU) | 2015-09-09 | — | — | CN | disclosed |
| US-8871937-B2 | 8-hydroxy-quinoline derivatives | “AVIDIN” Kutato, Fejleszto es Kereskedelmi Korlatolt Felelossegu Tarsasag (HU) | 2014-10-28 | — | — | US | disclosed |
| US-20130131096-A1 | 8-HYDROXY-QUINOLINE DERIVATIVES | UBICHEM KUTATO KORLATOLT FELELOSSEGU TARSASAG (HU) | 2013-05-23 | — | — | US | disclosed |
| CN-102985407-A | 8-hydroxy-quinoline derivatives | AVIDIN KUTATO FEJLESZTO ES KERESKEDELMI KORLATOLT FELELOSSEGU TARSASAG | 2013-03-20 | — | — | CN | disclosed |
| EP-2566849-A1 | 8-HYDROXY-QUINOLINE DERIVATIVES | "Avidin" Kutató, Fejleszt És Kereskedelmi Korlatolt Felelossegu Tarsasag (HU) | 2013-03-13 | — | — | EP | disclosed |
| WO-2011148208-A1 | 8-HYDROXY-QUINOLINE DERIVATIVES | "AVIDIN" KUTATÓ, FEJLESZTŐ ÉS KERESKEDELMI KORLÁTOLT FELELŐSSÉGŰ TÁRSASÁG (HU) | 2011-12-01 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130131096-A1 | 8-HYDROXY-QUINOLINE DERIVATIVES | CYP2C8, NQO1, KEAP1 | NOS3 886/4885NOS1 1837/4885NOS2 1302/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.