Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRP | O00591 | 4/20 | 0.55 |
| ▸ | GABRD | O14764 | 4/20 | 0.55 |
| ▸ | GABRA1 | P14867 | 4/20 | 0.55 |
| ▸ | GABRB1 | P18505 | 4/20 | 0.55 |
| ▸ | GABRG2 | P18507 | 4/20 | 0.55 |
| ▸ | GABRB3 | P28472 | 4/20 | 0.55 |
| ▸ | GABRA5 | P31644 | 4/20 | 0.55 |
| ▸ | GABRA3 | P34903 | 4/20 | 0.55 |
| ▸ | GABRA2 | P47869 | 4/20 | 0.55 |
| ▸ | GABRB2 | P47870 | 4/20 | 0.55 |
| ▸ | GABRA4 | P48169 | 4/20 | 0.55 |
| ▸ | GABRE | P78334 | 4/20 | 0.55 |
| ▸ | GABRA6 | Q16445 | 4/20 | 0.55 |
| ▸ | GABRG1 | Q8N1C3 | 4/20 | 0.55 |
| ▸ | GABRG3 | Q99928 | 4/20 | 0.55 |
| ▸ | GABRQ | Q9UN88 | 4/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30078658 | 0.80 | ALDH1A1 (0.41) | ALDH1A1CYP3A4TDP1ALOX15MAPT | |
| SCHEMBL109187 | 0.80 | ALDH1A1 (0.41) | ALDH1A1CYP3A4TDP1ALOX15MAPT | |
| SCHEMBL2475369 | 0.80 | ALDH1A1 (0.47) | ALDH1A1TDP1MAPTKDM4ELMNA | |
| SCHEMBL920297 | 0.74 | GABRP (0.64) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL1700862 | 0.73 | NOS3 (0.48) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL1923229 | 0.73 | BACE1 (0.37) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL5355792 | 0.72 | GABRP (0.62) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| Hydrochloric Acid SCHEMBL921022 | 0.72 | GABRP (0.62) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL8560442 | 0.71 | KDM4E (0.45) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL25173715 | 0.71 | KDM4E (0.41) | GABRPGABRDGABRA1GABRB1GABRG2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10357576-B2 | 18F-labelled folate/antifolate analogues | MERECK & CIE (CH) | 2019-07-23 | — | — | US | disclosed |
| EP-2864329-B1 | 18F-LABELLED FOLATE/ANTIFOLATE ANALOGUES | Merck & Cie (CH) | 2018-09-26 | — | — | EP | disclosed |
| CN-104379585-B | 18Folic acid/antifol analog of F- labels | 默克及其合伙人公司 | 2018-07-06 | — | — | CN | disclosed |
| US-20150125390-A1 | 18F-LABELLED FOLATE/ANTIFOLATE ANALOGUES | Merck & Cie (CH) | 2015-05-07 | — | — | US | disclosed |
| EP-2864329-A1 | 18F-LABELLED FOLATE/ANTIFOLATE ANALOGUES | Merck & Cie (CH) | 2015-04-29 | — | — | EP | disclosed |
| CN-104379585-A | 18F-labelled folate/antifolate analogues | Merck & Cie | 2015-02-25 | — | — | CN | disclosed |
| WO-2013167653-A1 | 18F-LABELLED FOLATE/ANTIFOLATE ANALOGUES | Merck & Cie (CH) | 2013-11-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150125390-A1 | 18F-LABELLED FOLATE/ANTIFOLATE ANALOGUES | FOLR1, FOLR2, SLC19A1 | GABRP 1809/4885GABRD 2516/4885GABRA1 999/4885 |
| US-10357576-B2 | 18F-labelled folate/antifolate analogues | FOLR1, FOLR2, SLC19A1 | GABRP 1782/4885GABRD 2487/4885GABRA1 980/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.