Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 1/20 | 0.32 |
| ▸ | MAOB | P27338 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.32 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.32 |
| ▸ | CDK2 | P24941 | 1/20 | 0.32 |
| ▸ | KDR | P35968 | 1/20 | 0.32 |
| ▸ | TYMS | P04818 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | S100A4 | P26447 | 4/20 | 0.31 |
| ▸ | PTPRC | P08575 | 3/20 | 0.31 |
| ▸ | BCHE | P06276 | 2/20 | 0.31 |
| ▸ | ACHE | P22303 | 2/20 | 0.31 |
| ▸ | CES1 | P23141 | 2/20 | 0.31 |
| ▸ | PMM2 | O15305 | 1/20 | 0.31 |
| ▸ | MPI | P34949 | 1/20 | 0.31 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.30 |
| ▸ | KCNJ1 | P48048 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2126356 | 0.80 | TXNRD1 (0.38) | ALDH1A1TYMSCYP3A4PMM2MPI | |
| SCHEMBL18251571 | 0.76 | HTR2A (0.39) | MAOAMAOBALDH1A1PDGFRBCDK2 | |
| SCHEMBL25230927 | 0.75 | GRIN2D (0.35) | MAOAMAOBALDH1A1TYMSCYP3A4 | |
| SCHEMBL18251572 | 0.74 | MAPT (0.35) | MAOAMAOBALDH1A1PDGFRBCDK2 | |
| SCHEMBL14720202 | 0.74 | ABCC9 (0.36) | MAOAMAOBALDH1A1PDGFRBCDK2 | |
| SCHEMBL2731592 | 0.74 | HSD11B1 (0.35) | MAOAMAOBALDH1A1PDGFRBCDK2 | |
| SCHEMBL29758974 | 0.74 | MAPT (0.35) | MAOAMAOBALDH1A1PDGFRBCDK2 | |
| SCHEMBL2731628 | 0.74 | KCNJ1 (0.41) | MAOAMAOBALDH1A1PDGFRBCDK2 | |
| SCHEMBL13046531 | 0.73 | S100A4 (0.47) | ALDH1A1CYP3A4TSHRS100A4PTPRC | |
| SCHEMBL17128311 | 0.72 | PARP10 (0.51) | MAOAMAOBALDH1A1PDGFRBCDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3104702-B1 | FACTOR XIA INHIBITORS | MERCK SHARP & DOHME LLC (US) | 2022-08-10 | — | — | EP | disclosed |
| US-9676723-B2 | Factor XIa inhibitors | MERCK SHARP & DOHME CORP (US) | 2017-06-13 | — | — | US | disclosed |
| US-9676723-B2 | Factor XIa inhibitors | MERCK SHARP & DOHME CORP (US) | 2017-06-13 | — | — | US | disclosed |
| US-9676723-B2 | Factor XIa inhibitors | MERCK SHARP & DOHME CORP (US) | 2017-06-13 | — | — | US | disclosed |
| EP-3104702-A1 | FACTOR XIA INHIBITORS | Merck Sharp & Dohme Corp. (US) | 2016-12-21 | — | — | EP | disclosed |
| US-20160340315-A1 | FACTOR XIa INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2016-11-24 | — | — | US | disclosed |
| US-20160340315-A1 | FACTOR XIa INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2016-11-24 | — | — | US | disclosed |
| US-20160340315-A1 | FACTOR XIa INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2016-11-24 | — | — | US | disclosed |
| WO-2015123091-A1 | FACTOR XIA INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2015-08-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160340315-A1 | FACTOR XIa INHIBITORS | F11, SERPINC1, TFPI | MAOA 799/4885MAOB 830/4885ALDH1A1 3635/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.