Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR7 | P34969 | 1/20 | 0.41 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.41 |
| ▸ | DCUN1D1 | Q96GG9 | 1/20 | 0.40 |
| ▸ | MBNL1 | Q9NR56 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | CASP3 | P42574 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.38 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.38 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.38 |
| ▸ | MAP4K1 | Q92918 | 2/20 | 0.37 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.36 |
| ▸ | PIM1 | P11309 | 3/20 | 0.36 |
| ▸ | IDO1 | P14902 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9099313 | 0.79 | HSP90AA1 (0.47) | HTR7HSP90AA1DCUN1D1MBNL1TDP1 | |
| SCHEMBL31468297 | 0.76 | HTR7 (0.44) | HTR7HSP90AA1DCUN1D1MBNL1TDP1 | |
| SCHEMBL1701249 | 0.70 | KDM4E (0.41) | TDP1POLBMAPTHPGDKDM4E | |
| SCHEMBL9278955 | 0.70 | TDP1 (0.40) | HTR7HSP90AA1DCUN1D1MBNL1TDP1 | |
| SCHEMBL1701209 | 0.69 | HSP90AA1 (0.48) | HSP90AA1TDP1POLBMAPTHPGD | |
| SCHEMBL397005 | 0.66 | IDO1 (0.46) | HTR7HSP90AA1DCUN1D1MBNL1TDP1 | |
| SCHEMBL2585043 | 0.66 | TTK (0.40) | HPGDKDM4EPIM1 | |
| SCHEMBL27511626 | 0.65 | HSP90AA1 (0.49) | HTR7HSP90AA1MAPTSMN1; SMN2KDM4E | |
| SCHEMBL11269697 | 0.65 | HSP90AA1 (0.56) | HSP90AA1MAPTSMN1; SMN2MAP4K1PIM1 | |
| SCHEMBL11625109 | 0.65 | MBNL1 (0.47) | HTR7HSP90AA1DCUN1D1MBNL1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2563776-A2 | COMPOUNDS THAT MODULATE INTRACELLULAR CALCIUM | Calcimedica, Inc. (US) | 2013-03-06 | — | — | EP | disclosed |
| WO-2011139489-A2 | COMPOUNDS THAT MODULATE INTRACELLULAR CALCIUM | CALCIMEDICA INC. (US) | 2011-11-10 | — | — | WO | disclosed |