SCHEMBL1701209

SCHEMBL1701209

Cc1c(-c2ccco2)n[nH]c1B(O)O

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HSP90AA1 P07900 1/20 0.48
HSP90AB1 P08238 1/20 0.48
PDE10A Q9Y233 1/20 0.44
KDM4E B2RXH2 9/20 0.43
TDP1 Q9NUW8 5/20 0.43
ALDH1A1 P00352 5/20 0.43
HPGD P15428 5/20 0.43
HSD17B10 Q99714 4/20 0.43
MEN1 O00255 4/20 0.43
POLB P06746 4/20 0.43
MAPT P10636 4/20 0.43
KMT2A Q03164 4/20 0.43
ALOX15 P16050 3/20 0.43
PTPN7 P35236 3/20 0.43
RECQL P46063 3/20 0.43
BLM P54132 3/20 0.43
PKM P14618 2/20 0.43
CASP1 P29466 2/20 0.43
CASP7 P55210 2/20 0.43
L3MBTL1 Q9Y468 2/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10305768 0.76 ADORA2A (0.49) HSP90AA1HSP90AB1PDE10AKDM4ETDP1
SCHEMBL2585043 0.72 TTK (0.40) KDM4EALDH1A1HPGDHSD17B10ADORA2A
SCHEMBL1701249 0.70 KDM4E (0.41) KDM4ETDP1ALDH1A1HPGDHSD17B10
SCHEMBL1701438 0.69 HTR7 (0.41) HSP90AA1KDM4ETDP1HPGDPOLB
SCHEMBL2592508 0.69 TAAR1 (0.51) HSP90AA1HSP90AB1PDE10AKDM4ETDP1
SCHEMBL13337900 0.66 HSP90AA1 (0.51) HSP90AA1HSP90AB1PDE10AKDM4ETDP1
SCHEMBL13366509 0.66 HSP90AA1 (0.51) HSP90AA1HSP90AB1PDE10AKDM4ETDP1
SCHEMBL28446161 0.66 ALDH1A1 (0.62) HSP90AA1HSP90AB1PDE10AKDM4ETDP1
SCHEMBL1701229 0.65 PDPK1 (0.40) HSP90AA1HSP90AB1PDE10AKDM4ETDP1
SCHEMBL26905277 0.65 MAPT (0.52) HSP90AA1HSP90AB1PDE10AKDM4ETDP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2563776-A2 COMPOUNDS THAT MODULATE INTRACELLULAR CALCIUM Calcimedica, Inc. (US) 2013-03-06 EP disclosed
WO-2011139489-A2 COMPOUNDS THAT MODULATE INTRACELLULAR CALCIUM CALCIMEDICA INC. (US) 2011-11-10 WO disclosed