Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PABPC1 | P11940 | 2/20 | 0.37 |
| ▸ | IDH1 | O75874 | 1/20 | 0.34 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.32 |
| ▸ | DRD2 | P14416 | 1/20 | 0.32 |
| ▸ | DRD4 | P21917 | 1/20 | 0.32 |
| ▸ | DRD3 | P35462 | 1/20 | 0.32 |
| ▸ | F2 | P00734 | 1/20 | 0.32 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.31 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.31 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.31 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.31 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.31 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.31 |
| ▸ | LTA4H | P09960 | 1/20 | 0.30 |
| ▸ | EGFR | P00533 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17019401 | 0.78 | ALDH1A1 (0.39) | — | |
| SCHEMBL18608668 | 0.78 | KDR (0.35) | DRD2DRD4DRD3GABRA1LTA4H | |
| SCHEMBL20976745 | 0.78 | KDR (0.35) | DRD2DRD4DRD3GABRA1LTA4H | |
| SCHEMBL20976710 | 0.78 | KDR (0.35) | DRD2DRD4DRD3GABRA1LTA4H | |
| SCHEMBL17019403 | 0.73 | GAA (0.32) | — | |
| SCHEMBL24768084 | 0.63 | L3MBTL1 (0.51) | — | |
| SCHEMBL9357255 | 0.62 | TAAR1 (0.56) | IDH1DRD2DRD3LTA4H | |
| SCHEMBL23126687 | 0.60 | IDH1 (0.42) | PABPC1IDH1DRD2DRD3 | |
| SCHEMBL27600078 | 0.59 | TAAR1 (0.58) | — | |
| SCHEMBL20751464 | 0.58 | IDH1 (0.46) | IDH1DRD2DRD3LTA4H |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170065586-A1 | SGC STIMULATORS | IRONWOOD PHARMACEUTICALS, INC. (US) | 2017-03-09 | — | — | US | disclosed |
| US-9487508-B2 | SGC stimulators | IRONWOOD PHARMACEUTICALS, INC. (US) | 2016-11-08 | — | — | US | disclosed |
| US-20150232461-A1 | SGC STIMULATORS | IRONWOOD PHARMACEUTICALS, INC. (US) | 2015-08-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150232461-A1 | SGC STIMULATORS | GUCY1B1, GUCY1A1, PRKG1 | PABPC1 3245/4885IDH1 1787/4885P2RX7 204/4885 |
| US-20170065586-A1 | SGC STIMULATORS | GUCY1B1, GUCY1A1, PRKG1 | PABPC1 3245/4885IDH1 1787/4885P2RX7 204/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.