Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | RECQL | P46063 | 1/20 | 0.37 |
| ▸ | PARP1 | P09874 | 1/20 | 0.36 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.36 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.35 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.35 |
| ▸ | TRPM8 | Q7Z2W7 | 2/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | ADCY10 | Q96PN6 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17019402 | 0.78 | PABPC1 (0.37) | — | |
| SCHEMBL18608669 | 0.76 | TSHR (0.36) | ALDH1A1HPGDL3MBTL1PARP1ADORA3 | |
| SCHEMBL9044086 | 0.75 | PARP1 (0.41) | ALDH1A1HPGDGLATDP1POLB | |
| SCHEMBL17019403 | 0.75 | GAA (0.32) | — | |
| SCHEMBL14366318 | 0.67 | TSHR (0.46) | ALDH1A1TDP1POLBADORA3ADORA1 | |
| SCHEMBL2719491 | 0.66 | TAAR1 (0.40) | ALDH1A1L3MBTL1POLBPARP1ESR2 | |
| SCHEMBL4173670 | 0.64 | KDM4E (0.47) | ALDH1A1HPGDGLAPOLBMAPT | |
| SCHEMBL559559 | 0.63 | TAAR1 (0.56) | ALDH1A1HPGDL3MBTL1TDP1POLB | |
| SCHEMBL2752018 | 0.63 | SMN1; SMN2 (0.46) | ALDH1A1L3MBTL1TDP1POLBMAPT | |
| SCHEMBL28998728 | 0.62 | POLB (0.47) | ALDH1A1HPGDGLATDP1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170065586-A1 | SGC STIMULATORS | IRONWOOD PHARMACEUTICALS, INC. (US) | 2017-03-09 | — | — | US | disclosed |
| US-9487508-B2 | SGC stimulators | IRONWOOD PHARMACEUTICALS, INC. (US) | 2016-11-08 | — | — | US | disclosed |
| US-20150232461-A1 | SGC STIMULATORS | IRONWOOD PHARMACEUTICALS, INC. (US) | 2015-08-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150232461-A1 | SGC STIMULATORS | GUCY1B1, GUCY1A1, PRKG1 | ALDH1A1 1303/4885HPGD 146/4885GLA 747/4885 |
| US-20170065586-A1 | SGC STIMULATORS | GUCY1B1, GUCY1A1, PRKG1 | ALDH1A1 1303/4885HPGD 146/4885GLA 747/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.