Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Glyphosate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 5/20 | 0.40 |
| ▸ | CA1 | P00915 | 2/20 | 0.36 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.36 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.35 |
| ▸ | DNM1 | Q05193 | 2/20 | 0.34 |
| ▸ | FDPS | P14324 | 1/20 | 0.34 |
| ▸ | FABP3 | P05413 | 5/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Glyphosate SCHEMBL17748415 | 0.86 | FDPS (0.43) | CA2CA1NFKB1FDPSFABP3 | |
| Glyphosate SCHEMBL17748408 | 0.80 | FABP3 (0.42) | NFKB1DNM1FDPSFABP3 | |
| Tetrabuthylammonium SCHEMBL1702368 | 0.79 | SLC22A1 (0.39) | CA1FABP3 | |
| Glyphosate SCHEMBL18414 | 0.77 | CA12 (0.37) | CA2CA1 | |
| Glyphosate SCHEMBL18450 | 0.77 | CA4 (0.39) | CA2CA1 | |
| Glyphosate SCHEMBL3665222 | 0.77 | FOLH1 (0.38) | CA2CA1 | |
| Glyphosate SCHEMBL9756253 | 0.77 | CA4 (0.35) | CA2CA1 | |
| Glyphosate SCHEMBL7194092 | 0.77 | CA4 (0.35) | CA2CA1 | |
| Glyphosate SCHEMBL9947944 | 0.77 | CA4 (0.35) | CA2CA1 | |
| Glyphosate SCHEMBL3395373 | 0.77 | CA4 (0.35) | CA2CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130109572-A1 | HERBICIDAL COMPOSITIONS AND METHODS OF USE | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ALABAMA (US) | 2013-05-02 | — | — | US | disclosed |
| WO-2012006313-A2 | HERBICIDAL COMPOSITIONS AND METHODS OF USE | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ALABAMA (US) | 2012-01-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130109572-A1 | HERBICIDAL COMPOSITIONS AND METHODS OF USE | DDT, ACHE, CAT | CA2 926/4885CA1 1082/4885NFKB1 4697/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.