Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Glyphosate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FOLH1 | Q04609 | 3/20 | 0.38 |
| ▸ | CA4 | P22748 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | CA12 | O43570 | 1/20 | 0.32 |
| ▸ | CA1 | P00915 | 1/20 | 0.32 |
| ▸ | CA2 | P00918 | 1/20 | 0.32 |
| ▸ | CA9 | Q16790 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Glyphosate SCHEMBL7194092 | 0.95 | CA4 (0.35) | FOLH1CA4LMNACA12CA1 | |
| Glyphosate SCHEMBL3395373 | 0.95 | CA4 (0.35) | FOLH1CA4LMNACA12CA1 | |
| Glyphosate SCHEMBL9756253 | 0.95 | CA4 (0.35) | FOLH1CA4LMNACA12CA1 | |
| Glyphosate SCHEMBL18414 | 0.95 | CA12 (0.37) | FOLH1CA4LMNACA12CA1 | |
| Glyphosate SCHEMBL3394676 | 0.95 | CA4 (0.35) | FOLH1CA4LMNACA12CA1 | |
| Glyphosate SCHEMBL9947944 | 0.95 | CA4 (0.35) | FOLH1CA4LMNACA12CA1 | |
| Glyphosate SCHEMBL18450 | 0.95 | CA4 (0.39) | FOLH1CA4LMNACA12CA1 | |
| Glyphosate SCHEMBL3294894 | 0.93 | CA12 (0.35) | FOLH1CA4LMNACA12CA1 | |
| Glyphosate SCHEMBL1401794 | 0.89 | FOLH1 (0.32) | FOLH1CA4 | |
| Glyphosate SCHEMBL1701849 | 0.84 | BBOX1 (0.32) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100331185-A1 | Herbicidal Compositions of Lithium Glyphosate and Adjuvants | COGNIS IP MANAGEMENT GMBH (DE) | 2010-12-30 | — | — | US | disclosed |
| US-20100331185-A1 | Herbicidal Compositions of Lithium Glyphosate and Adjuvants | COGNIS IP MANAGEMENT GMBH (DE) | 2010-12-30 | — | — | US | disclosed |
| EP-2211622-A2 | HERBICIDAL COMPOSITIONS OF LITHIUM GLYPHOSATE AND ADJUVANTS | Cognis IP Management GmbH (DE) | 2010-08-04 | — | — | EP | disclosed |
| EP-2211622-A2 | HERBICIDAL COMPOSITIONS OF LITHIUM GLYPHOSATE AND ADJUVANTS | Cognis IP Management GmbH (DE) | 2010-08-04 | — | — | EP | disclosed |
| WO-2009068226-A3 | HERBICIDAL COMPOSITIONS OF LITHIUM GLYPHOSATE AND ADJUVANTS | COGNIS IP MAN GMBH (DE) | 2009-08-06 | — | — | WO | disclosed |
| WO-2009068226-A2 | HERBICIDAL COMPOSITIONS OF LITHIUM GLYPHOSATE AND ADJUVANTS | COGNIS IP MANAGEMENT GMBH (DE) | 2009-06-04 | — | — | WO | disclosed |
| WO-2009068226-A2 | HERBICIDAL COMPOSITIONS OF LITHIUM GLYPHOSATE AND ADJUVANTS | COGNIS IP MANAGEMENT GMBH (DE) | 2009-06-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100331185-A1 | Herbicidal Compositions of Lithium Glyphosate and Adjuvants | GRIK3, SLC6A5, GLRA3 | FOLH1 695/4885CA4 535/4885LMNA 2633/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.