Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.38 |
| ▸ | ADRA2A | P08913 | 5/20 | 0.35 |
| ▸ | ADRA2C | P18825 | 4/20 | 0.35 |
| ▸ | FGFR3 | P22607 | 4/20 | 0.35 |
| ▸ | ADRA1D | P25100 | 3/20 | 0.34 |
| ▸ | ADRA1A | P35348 | 3/20 | 0.34 |
| ▸ | ADRA1B | P35368 | 3/20 | 0.34 |
| ▸ | FFAR2 | O15552 | 1/20 | 0.34 |
| ▸ | PTGES | O14684 | 2/20 | 0.34 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | HPGDS | O60760 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.32 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17023146 | 0.83 | ADRA2A (0.34) | HSP90AA1ADRA2AADRA2CFGFR3ADRA1D | |
| SCHEMBL1126565 | 0.82 | FGFR3 (0.45) | FGFR3PTGESMAPTHSD17B10 | |
| SCHEMBL17023104 | 0.81 | FGFR3 (0.53) | FGFR3 | |
| SCHEMBL17023143 | 0.81 | HSP90AA1 (0.44) | HSP90AA1ADRA2AADRA2CFGFR3MAPT | |
| SCHEMBL17023080 | 0.80 | HSP90AA1 (0.38) | HSP90AA1ADRA2AFGFR3NR3C1MAPT | |
| SCHEMBL17023129 | 0.76 | FGFR3 (0.46) | HSP90AA1FGFR3MAPTKDM4EMEN1 | |
| SCHEMBL17023018 | 0.76 | FGFR3 (0.45) | HSP90AA1FGFR3NR3C1MAPTKDM4E | |
| SCHEMBL17023046 | 0.76 | FGFR3 (0.42) | FGFR3 | |
| SCHEMBL17023037 | 0.75 | HPGDS (0.44) | HSP90AA1ADRA2AADRA2CFGFR3ADRA1D | |
| SCHEMBL17023123 | 0.74 | HRH3 (0.52) | HSP90AA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2282995-B1 | DERIVATIVES OF QUINOLINES AND QUINOXALINES AS PROTEIN TYROSINE KINASE INHIBITORS | NOVARTIS AG (CH) | 2015-08-26 | — | — | EP | claimed |