Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR3 | P22607 | 2/20 | 0.46 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.39 |
| ▸ | CYP17A1 | P05093 | 12/20 | 0.37 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.34 |
| ▸ | WNT1 | P04628 | 1/20 | 0.34 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.34 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.34 |
| ▸ | NAMPT | P43490 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.33 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17023143 | 0.89 | HSP90AA1 (0.44) | FGFR3HSP90AA1ROCK2CYP3A4KDM4E | |
| SCHEMBL1126454 | 0.84 | FGFR3 (0.59) | FGFR3SLC22A12WNT1DYRK1AKDM4E | |
| SCHEMBL17023080 | 0.80 | HSP90AA1 (0.38) | FGFR3HSP90AA1KDM4EMEN1MAPT | |
| SCHEMBL17023018 | 0.80 | FGFR3 (0.45) | FGFR3HSP90AA1KDM4EMEN1MAPT | |
| SCHEMBL17023025 | 0.78 | FGFR3 (0.59) | FGFR3DYRK1AKDM4E | |
| SCHEMBL17023109 | 0.76 | HRH3 (0.41) | FGFR3HSP90AA1CYP17A1KDM4E | |
| SCHEMBL17023184 | 0.76 | HSP90AA1 (0.38) | FGFR3HSP90AA1KDM4EMEN1MAPT | |
| SCHEMBL17023146 | 0.75 | ADRA2A (0.34) | FGFR3HSP90AA1CYP3A4 | |
| SCHEMBL17023180 | 0.74 | NPC1 (0.49) | FGFR3MEN1MAPTKMT2ANPSR1 | |
| SCHEMBL17023126 | 0.73 | FGFR3 (0.77) | FGFR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2282995-B1 | DERIVATIVES OF QUINOLINES AND QUINOXALINES AS PROTEIN TYROSINE KINASE INHIBITORS | NOVARTIS AG (CH) | 2015-08-26 | — | — | EP | claimed |