Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 3/20 | 0.45 |
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.44 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | TSHR | P16473 | 4/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17023221 | 0.91 | L3MBTL1 (0.47) | NPC1RAB9ASMN1; SMN2LMNAMAPT | |
| SCHEMBL17023210 | 0.87 | USP2 (0.41) | RAB9ASMN1; SMN2LMNAMAPTNPSR1 | |
| SCHEMBL1877072 | 0.86 | NPC1 (0.48) | NPC1RAB9ASMN1; SMN2LMNAMAPT | |
| SCHEMBL17023229 | 0.86 | L3MBTL1 (0.48) | NPC1RAB9ASMN1; SMN2LMNAMAPT | |
| SCHEMBL17023233 | 0.85 | KMT2A (0.46) | SMN1; SMN2LMNAALDH1A1MEN1KMT2A | |
| SCHEMBL17023227 | 0.85 | L3MBTL1 (0.45) | SMN1; SMN2LMNAMAPTNPSR1TDP1 | |
| SCHEMBL17023217 | 0.82 | LMNA (0.52) | NPC1RAB9ASMN1; SMN2LMNAMAPT | |
| SCHEMBL17023231 | 0.82 | LMNA (0.46) | NPC1RAB9ASMN1; SMN2LMNAMAPT | |
| SCHEMBL17023212 | 0.82 | ALDH1A1 (0.49) | NPC1RAB9ASMN1; SMN2LMNAMAPT | |
| SCHEMBL17023215 | 0.80 | KDM4E (0.49) | NPC1RAB9ASMN1; SMN2MAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2059503-B1 | AMINOPYRAZOLE DERIVATIVES, PROCESS FOR THE PREPARATION THEREOF, AND COMPOSITION FOR PREVENTING OR TREATING ISCHEMIC DISEASES CONTAINING THE SAME | KOREA RES INST CHEM TECH (KR) | 2015-08-26 | — | — | EP | claimed |