Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.40 |
| ▸ | MGLL | Q99685 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | CA12 | O43570 | 4/20 | 0.36 |
| ▸ | CA7 | P43166 | 1/20 | 0.36 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | CA1 | P00915 | 3/20 | 0.33 |
| ▸ | CA9 | Q16790 | 3/20 | 0.33 |
| ▸ | CA2 | P00918 | 2/20 | 0.33 |
| ▸ | TTR | P02766 | 1/20 | 0.33 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.32 |
| ▸ | PDK1 | Q15118 | 2/20 | 0.32 |
| ▸ | PDK2 | Q15119 | 2/20 | 0.32 |
| ▸ | PDK3 | Q15120 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5526972 | 0.97 | TSHR (0.44) | TSHRMGLLALDH1A1CA12CA7 | |
| SCHEMBL1582709 | 0.97 | TSHR (0.44) | TSHRMGLLALDH1A1CA12CA7 | |
| SCHEMBL718510 | 0.97 | TSHR (0.44) | TSHRMGLLALDH1A1CA12CA7 | |
| Hydrochloric Acid SCHEMBL28974479 | 0.94 | TSHR (0.42) | TSHRMGLLALDH1A1CA12CA7 | |
| SCHEMBL6300105 | 0.93 | TSHR (0.43) | TSHRMGLLALDH1A1CA12CA7 | |
| SCHEMBL31348042 | 0.90 | ALDH1A1 (0.44) | TSHRMGLLALDH1A1CA12CA7 | |
| SCHEMBL236146 | 0.89 | MGLL (0.47) | TSHRMGLLALDH1A1CA12CA7 | |
| Hydrochloric Acid SCHEMBL28019904 | 0.85 | MGLL (0.44) | TSHRMGLLALDH1A1CA12CA7 | |
| SCHEMBL19878897 | 0.85 | — | — | |
| SCHEMBL5866410 | 0.82 | TSHR (0.34) | TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 256 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240101542-A1 | ERAP INHIBITORS | INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (FR) | 2024-03-28 | — | — | US | claimed |
| EP-4263533-A1 | ERAP INHIBITORS | Université de Lille (FR) | 2023-10-25 | — | — | EP | claimed |
| WO-2022129589-A9 | ERAP INHIBITORS | UNIVERSITE DE LILLE (FR) | 2023-08-24 | — | — | WO | claimed |
| WO-2022129589-A1 | ERAP INHIBITORS | UNIVERSITE DE LILLE (FR) | 2022-06-23 | — | — | WO | claimed |
| US-10221172-B2 | Benzothiazole and benzisothiazole-substituted compounds as mGluR4 allosteric potentiators, compositions, and methods of treating neurological dysfunction | VANDERBILT UNIVERSITY (US) | 2019-03-05 | — | — | US | claimed |
| US-20180022744-A1 | BENZOTHIAZOLE AND BENZISOTHIAZOLE-SUBSTITUTED COMPOUNDS AS MGLUR4 ALLOSTERIC POTENTIATORS, COMPOSITIONS, AND METHODS OF TREATING NEUROLOGICAL DYSFUNCTION | VANDERBILT UNIVERSITY | 2018-01-25 | — | — | US | claimed |
| WO-2016115272-A1 | BENZOTHIAZOLE AND BENZISOTHIAZOLE-SUBSTITUTED COMPOUNDS AS MGLUR4 ALLOSTERIC POTENTIATORS, COMPOSITIONS, AND METHODS OF TREATING NEUROLOGICAL DYSFUNCTION | VANDERBILT UNIVERSITY (US) | 2016-07-21 | — | — | WO | claimed |
| WO-2015173321-A1 | COMPOSITION FOR DYEING KERATIN FIBRES, COMPRISING A PARTICULAR IMIDAZOLE COUPLER AND AN OXIDATION BASE | L'OREAL (FR) | 2015-11-19 | — | — | WO | claimed |
| EP-1809601-B1 | COMPOUNDS FOR ALZHEIMER'S DISEASE | MANFREDI JOHN (US) | 2014-09-10 | — | — | EP | claimed |
| US-8569291-B2 | Bicyclic dihydroimidazolone CGRP receptor antagonists | MERCK SHARP & DOHME CORP. (US) | 2013-10-29 | — | — | US | claimed |
| EP-1073641-B1 | NEW SUBSTITUTED AMIDES, THEIR PRODUCTION AND THEIR USE | ABBOTT GMBH & CO KG (DE) | 2004-04-14 | — | — | EP | claimed |
| WO-2004009563-A1 | 5-ARYLTETRAZOLE COMPOUNDS, COMPOSITIONS THEREOF, AND USES THEREFOR | INOTEK PHARMACEUTICALS CORPORATION (US) | 2004-01-29 | — | — | WO | claimed |
| US-20040019208-A1 | 5-Aryltetrazole Compounds, compositions thereof, and uses therefor | INOTEK PHARMACEUTICALS CORPORATION | 2004-01-29 | — | — | US | claimed |
| EP-0362119-B1 | IMPROVED PROCESS FOR THE CATALYZED SYNTHESIS OF N-SUBSTITUTED ACRYLAMIDES AND METHACRYLAMIDES | THE GOODYEAR TIRE & RUBBER COMPANY (US) | 1993-07-28 | — | — | EP | claimed |
| EP-0213718-B1 | 1-DIMETHYLCARBAMOYL-3-SUBSTITUTED-5-SUBSTITUTED-1H-1,2,4-TRIAZOLES | ROHM AND HAAS COMPANY (US) | 1991-06-12 | — | — | EP | claimed |
| EP-0213718-A2 | 1-Dimethylcarbamoyl-3-substituted-5-substituted-1H-1,2,4-triazoles | ROHM AND HAAS COMPANY (US) | 1987-03-11 | — | — | EP | claimed |
| EP-0099802-B1 | THIENO(3,2-C) PYRIDINE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR THERAPEUTICAL USE | ELF SANOFI (FR) | 1987-02-04 | — | — | EP | claimed |
| US-4540523-A | Phenylalkylamino-styryl dyestuffs | BAYER AKTIENGESELLSCHAFT (DE) | 1985-09-10 | — | — | US | claimed |
| EP-0029617-B1 | USE OF TERTIARY HETEROCYCLIC AMINES AS SYNERGISTS IN PESTICIDES; DERIVATIVES OF CYCLOAMINES | C.F. Spiess & Sohn GmbH & Co. Chemische Fabrik (DE) | 1984-09-12 | — | — | EP | claimed |
| EP-0068968-A1 | Medicines containing as active ingredients compounds of the arylbenzenesulfonamide-type, and processes for their preparation | CHOAY S.A. (FR) | 1983-01-05 | — | — | EP | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240101542-A1 | ERAP INHIBITORS | ERAP2, ERAP1, ERMP1 | TSHR 3799/4885MGLL 2989/4885ALDH1A1 2756/4885 |
| US-20180022744-A1 | BENZOTHIAZOLE AND BENZISOTHIAZOLE-SUBSTITUTED COMPOUNDS AS MGLUR4 ALLOSTERIC POTENTIATORS, COMPOSITIONS, AND METHODS OF TREATING NEUROLOGICAL DYSFUNCTION | GRM4, GRIK4, GRIA4 | TSHR 604/4885MGLL 3293/4885ALDH1A1 3825/4885 |
| US-10221172-B2 | Benzothiazole and benzisothiazole-substituted compounds as mGluR4 allosteric potentiators, compositions, and methods of treating neurological dysfunction | GRM4, GRIK4, GRIA4 | TSHR 604/4885MGLL 3293/4885ALDH1A1 3825/4885 |
| US-20040019208-A1 | 5-Aryltetrazole Compounds, compositions thereof, and uses therefor | CASP5, NLRP3, LITAF | TSHR 2397/4885MGLL 553/4885ALDH1A1 944/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.